Abstract
Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N=4) or agoraphobia with panic attacks (N=17) and age- and sex-matched healthy subjects (N=22). The patients showed a significantly lower number of β-adrenergic receptor binding sites and a significantly higher affinity of binding than healthy subjects. A past or present history of major depression in the patients did not alter these findings. These results are consistent with a growing body of knowledge implicating noradrenergic dysfunction in the pathophysiology of panic anxiety.
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Brown, S.L., Charney, D.S., Woods, S.W. et al. Lymphocyte β-adrenergic receptor binding in panic disorder. Psychopharmacology 94, 24–28 (1988). https://doi.org/10.1007/BF00735875
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DOI: https://doi.org/10.1007/BF00735875