Skip to main content
SpringerLink
Log in

N-Glycosylation/deglycosylation as a mechanism for the post-translational modification/remodification of proteins

  • Glycopinion Mini-Review
  • Published:
Glycoconjugate Journal Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

PNGase:

peptide-N4-(N-acetyl-b-d-glucosaminyl) asparagine amidase or peptide:N-glycanase

endo-b-GlcNAc'ase:

endo-b-N-acetyl-d-glucosaminidase

GPP:

glycophosphoproteins

L-929 PNGase:

PNGase isolated from C3H mouse-derived fibroblast cells, L-929

UNGs:

unconjugated N-glycans

Xyl:

xylose

Gal:

galactose

Ara:

arabinose

Con A:

concanavalin A

RER:

rough endoplasmic reticulum

Man5GlcNAc2-pyrophosphoryl dolichol:

pentamannosyl N,N′-diacetylchitobiosyl pyrophosphoryl dolichol

References

  1. Varki A (1993)Glycobiology 3:97–130.

    Google Scholar 

  2. Blithe DL (1993)Trends Glycosci Glycotechnol 5:81–98.

    Google Scholar 

  3. Lis H, Sharon N (1993)Eur J Biochem 218:1–27.

    Google Scholar 

  4. Takahashi N (1977)Biochem Biophys Res Commun 76: 1194–1201.

    Google Scholar 

  5. Plummer TH Jr, Phelan AW, Tarentino AL (1987)Eur J Biochem 163:167–73.

    Google Scholar 

  6. Plummer TH Jr, Elder JH, Alexander S, Phelan AW, Tarentino AL (1984)J Biol Chem 259: 10700–4.

    Google Scholar 

  7. Seko A, Kitajima K, Inoue Y, Inoue S (1991)J Biol Chem 266:22110–14.

    Google Scholar 

  8. Inoue S, Iwasaki M, Kitajima K, Seko A, Inoue Y (1993)Glycoconjugate J 10:223.

    Google Scholar 

  9. Suzuki T, Seko A, Kitajima K, Inoue Y, Inoue S (1993)Biochem Biophys Res Commun 194:1124–30.

    Google Scholar 

  10. Suzuki T, Seko A, Kitajima K, Inoue Y, Inoue S (1993)Glycoconjugate J 10:223.

    Google Scholar 

  11. Suzuki T, Kouchi Z, Seko A, Kitajima K, Inoue S, Inoue Y (1994) Abstracts of XVIIth International Carbohydrate Symposium: p. 430, July 17–22, Ottawa, Canada.

  12. Kitajima K, Suzuki T, Kouchi Z, Inoue S, Inoue Y, (1995)Arch Biochem Biophys, in press.

  13. Suzuki T, Seko A, Kitajima K, Inoue Y, Inoue S (1994)J Biol Chem 269:17611–18.

    Google Scholar 

  14. Inoue S (1990)Trends Glycosci Glycotechnol 2:225–34.

    Google Scholar 

  15. Suzuki T, Kitajima K, Inoue S, Inoue Y (1994)Glycobiology 4:779–89.

    Google Scholar 

  16. Lhernould S, Karamanos Y, Bourgenie S, Strecker G, Julien R, Morvan H (1992)Glycoconjugate J 9:191–97.

    Google Scholar 

  17. Ishii K, Iwasaki M, Inoue S, Kenny PTM, Komura H, Inoue Y (1989)J Biol Chem 264:1623–30.

    Google Scholar 

  18. Inoue S, Iwasaki M, Ishii K, Kitajima K, Inoue Y (1989)J Biol Chem 264:18520–26.

    Google Scholar 

  19. Iwasaki M, Seko A, Kitajima K, Inoue Y, Inoue S (1992)J Biol Chem 267:24287–96.

    Google Scholar 

  20. Seko A, Kitajima K, Iwasaki M, Inoue S, Inoue Y (1989)J Biol Chem 264:15922–29.

    Google Scholar 

  21. Seko A, Kitajima K, Inoue S, Inoue Y (1991)Biochem Biophys Res Commun 180:1165–71.

    Google Scholar 

  22. Taguchi T, Seko A, Kitajima K, Inoue S, Iwamatsu T, Khoo K-H, Morris HR, Dell A, Inoue Y (1993)J Biol Chem 268:2353–62.

    Google Scholar 

  23. Taguchi T, Seko A, Kitajima K, Muto Y, Inoue S, Khoo K-H, Morris HR, Dell A, Inoue Y (1994)J Biol Chem 269:8762–71.

    Google Scholar 

  24. Kitajima K, Inoue S, Inoue Y (1989)Dev Biol 132:544–53.

    Google Scholar 

  25. Suzuki T, Kitajima K, Inoue S, Inoue Y (1994)Glycoconjugate J 11:469–76.

    Google Scholar 

  26. Muramatsu T (1971)J Biol Chem 246:5535–37.

    Google Scholar 

  27. Overdijk B, Koref MJVD, Lisman JJW, Pierce RJ, Montreuil J, Spik G (1981)FEBS Lett 128:364–66.

    Google Scholar 

  28. De Gasperi R, Li Y-T, Li S-C (1989)J Biol Chem 264:9329–34.

    Google Scholar 

  29. Tachibana Y, Yamashita K, Kawaguchi M, Arashima S, Kobata A (1981)J Biochem 90:1291–96.

    Google Scholar 

  30. Li Y-T, De Gasperi R, Townsend RR, Cousins JC, Lee Y-C, Li S-C (1985) Abstracts of Proceeding of the VIIIth International Symposium on Glycoconjugates: pp. 71–72, September 8–13, Houston, TX.

  31. Ito K, Okada Y, Ishida K, Minamiura N (1993)J Biol Chem 268:16074–81.

    Google Scholar 

  32. Nishigaki M, Muramatsu T, Kobata A (1974)Biochem Biophys Res Commun 59:638–45.

    Google Scholar 

  33. Pierce RJ, Spik G, Montreuil J (1979)Biochem J 180:673–76.

    Google Scholar 

  34. Pierce RJ, Spik G, Montreuil J (1980)Biochem J 185:261–64.

    Google Scholar 

  35. Tachibana Y, Yamashita K, Kobata A (1982)Arch Biochem Biophys 214:199–210.

    Google Scholar 

  36. Lisman JJW, Van den Wal CJ, Overdijk B (1985)Biochem J 229:379–85.

    Google Scholar 

  37. Haeuw J-F, Michalski J-C, Strecker G, Spik G, Montreuil J (1991)Glycobiology 1:487–92.

    Google Scholar 

  38. Anumula KR, Spiro RG (1983)J Biol Chem 258:15274–82.

    Google Scholar 

  39. Delmonte F, Kieda C, Montsigny M (1976)CR Acad Sci Paris 283:1121–24.

    Google Scholar 

  40. Tarentino AL, Maley F (1976)J Biol Chem 251:6537–43.

    Google Scholar 

  41. Maley F, Trimble RB, Tarentino AL, Plummer TH Jr (1989)Anal Biochem 180:195–204.

    Google Scholar 

  42. Kuranda MJ, Aronson NN Jr (1985)J Biol Chem 261:5803–9.

    Google Scholar 

  43. Fisher KJ, Aronson NN Jr (1992)J Biol Chem 267:19607–16.

    Google Scholar 

  44. Brassart D, Baussant T, Wieruszeski J-M, Strecker G, Montreuil J, Michalski J-C (1987)Eur J Biochem 169: 131–36.

    Google Scholar 

  45. Aronson NN Jr, Kuranda MJ (1989)FASEB J 3:2615–22.

    Google Scholar 

  46. Opresko L, Wiley HS, Wallace RA (1980)Cell 22:47–57.

    Google Scholar 

  47. Busson-Mabillot S (1984)Biol Cell 51:53–66.

    Google Scholar 

  48. Bell AA (1981)Annu Rev Plant Physiol 32:21–81.

    Google Scholar 

  49. Hahlbrock K, Scheel D (1989)Annu Rev Plant Physiol Plant Mol Biol 40:347–69.

    Google Scholar 

  50. Dixon RA, Lamb CJ (1990)Annu Rev Plant Physiol Plant Mol Biol 41:339–67.

    Google Scholar 

  51. Scheel D, Parker JE (1990)Z Naturforsch Sect C Biosci 45:569–75.

    Google Scholar 

  52. Basse CW, Bock K, Boller T (1992)J Biol Chem 267:10258–65.

    Google Scholar 

  53. Basse CW, Boller T (1992)Plant Physiol 98:1239–47.

    Google Scholar 

  54. Basse CW, Fath A, Boller T (1993)J Biol Chem 268:14724–31.

    Google Scholar 

  55. Inoue S, Inoue Y (1986)J Biol Chem 261:5256–61.

    Google Scholar 

  56. Inoue S, Kitajima K, Inoue Y, Kudo S (1987)Dev Biol 123:442–54.

    Google Scholar 

  57. Kitajima K, Inoue S (1988)Dev Biol 129:270–74.

    Google Scholar 

  58. Priem B, Morvan H, Gross KC (1994)Biochem Soc Trans 22:398–402.

    Google Scholar 

  59. Priem B, Solokwan J, Wieruszeski J-M, Strecker G, Nazih H, Morvan H (1990)Glycoconjugate J 7:121–32.

    Google Scholar 

  60. Priem B, Gitti R, Bush CA, Gross KC (1993)Plant Physiol 102:445–58.

    Google Scholar 

  61. Priem B, Morvan H, Monim A, Hafez A, Morvan C (1990)C R Acad Sci Paris 311:411–16.

    Google Scholar 

  62. Priem B, Gross KC (1992)Plant Physiol 98:399–401.

    Google Scholar 

  63. Yunovitz H, Gross KC (1994)Physiol Plant 90:152–56.

    Google Scholar 

  64. Yunovitz H, Gross KC (1994) Abstracts of XVIIth International Carbohydrate Symposium: p. 390, July 17–22, Ottawa, Canada.

  65. Herman EM, Shannon LM, Chrispeels MJ (1985)Planta 165:23–29.

    Google Scholar 

  66. Bowles DJ, Marcus SE, Pappin DJC, Findley JBC, Eliopoulos E, Maycox PR, Burgess J (1986)J Cell Biol 102:1284–97.

    Google Scholar 

  67. Sheldon PS, Bowles DJ (1992)EMBO J 11:1297–1301.

    Google Scholar 

  68. Min W, Dunn AJ, Jones DH (1992)EMBO J 11:1303–7.

    Google Scholar 

  69. Sugiyama K, Ishihara H, Tejima S, Takahashi N (1983)Biochem Biophys Res Commun 112:155–60.

    Google Scholar 

  70. Yet M-G, Wold F (1988)J Biol Chem 263:118–22.

    Google Scholar 

  71. Wilkins TA, Bednarek SY, Raikhel NV (1990)Plant Cell 2:301–13.

    Google Scholar 

  72. Raikhel NV, Wilkins TA (1987)Proc Natl Acad Sci USA 84:6745–49.

    Google Scholar 

  73. Lerner DR, Raikhel NV (1989)Plant Physiol 91:124–29.

    Google Scholar 

  74. Wood KA, Lord JM, Wawrzynczak EJ, Piatak M (1991)Eur J Biochem 198:723–32.

    Google Scholar 

  75. Van Damme EJM, Smeets K, Torrekens S, Van Leuven F, Peumans WJ (1994)Eur J Biochem 221:769–77.

    Google Scholar 

  76. Sinha YN (1992)Trends Endocrinol Metab 3:100–6.

    Google Scholar 

  77. Lewis UJ, Singh RNP, Lewis LJ, Seavey BK, Sinha YN (1984)Proc Natl Acad Sci USA 81:385–89.

    Google Scholar 

  78. Lewis UJ, Singh RNP, Sinha YN, Vanderlaan WP (1985)Endocrinology 136:359–63.

    Google Scholar 

  79. Pankov YA, Butnev VY (1986)Int J Peptide Prot Res 28:113–23.

    Google Scholar 

  80. Sinha YN, Jacobsen BP (1987)Biochem Biophys Res Commun 148:505–14.

    Google Scholar 

  81. Martitat N, Anouassi A, Huet J-C, Pernollet JC, Combarnous Y (1990)Comp Biochem Physiol 97B:667–74.

    Google Scholar 

  82. Corcoran DH, Proudman JA (1991)Comp Biochem Physiol 99B:563–70.

    Google Scholar 

  83. Noso T, Swanson P, Lance VA, Kawauchi H (1992)Int J Peptide Prot Res 39:250–57.

    Google Scholar 

  84. Nyberg F, Roos P, Wide K (1980)Biochim Biophys Acta 625:255–65.

    Google Scholar 

  85. Hoffman T, Penel C, Ronin C (1993)J Endocrinol Invest 16:807–16.

    Google Scholar 

  86. Markoff E, Sigel MB, Lacour N, Seavey BK, Friesen HG, Lewis UJ (1988)Endocrinology 123:1303–6.

    Google Scholar 

  87. Spiro MJ, Spiro RG (1991)J Biol Chem 266:5311–17.

    Google Scholar 

  88. Cacan R, Villers C, Belard M, Kaiden A, Krag S, Verbert A (1992)Glycobiology 2:127–36.

    Google Scholar 

  89. Villers C, Cacan R, Mir A-M, Labiau O, Verbert A (1994)Biochem J 298:135–42.

    Google Scholar 

  90. Moore SEH, Spiro RG (1994)J Biol Chem 269:12715–21.

    Google Scholar 

  91. Klausner RD, Sitia R. (1990)Cell 62:611–14.

    Google Scholar 

  92. Bonifacino JS, Lippincott-Schwartz J (1991)Curr Opin Cell Biol 3:592–600.

    Google Scholar 

  93. Stafford FJ, Bonifacino JS (1991)J Cell Biol 115:1225–36.

    Google Scholar 

  94. Lennarz WJ (1987)Biochemistry 26:7205–10.

    Google Scholar 

  95. Roth J (1987)Biochim Biophys Acta 906:405–36.

    Google Scholar 

  96. Pedemonte CH, Sachs G, Kaplan JH (1990)Proc Natl Acad Sci USA 87:9789–93.

    Google Scholar 

  97. Kaplan JH, Pedemonte CH (1992)Biochemistry 31:10465–70.

    Google Scholar 

  98. Aquino DA, Margolis RU, Margolis RK (1984)J Cell Biol 99:1117–29.

    Google Scholar 

  99. Aquino DA, Margolis RU, Margolis RK (1984)J Cell Biol 99:1130–39.

    Google Scholar 

  100. Hirschberg CB, Snider MD (1987)Annu Rev Biochem 56:63–87.

    Google Scholar 

  101. Abeijon C, Hirschberg CB (1992)Trends Biochem Sci 17:32–36.

    Google Scholar 

  102. Troy FA, Janas T, Janas T, Merker RL (1991)Glycoconjugate J 8:153.

    Google Scholar 

  103. Nilsson B, DeLusa S, Lohmander S, Hascall VC (1982)J Biol Chem 257:10920–27.

    Google Scholar 

  104. Wall DA, Patel S (1987)Dev Biol 119:275–89.

    Google Scholar 

  105. Tarentino AL, Quinones G, Trumble A, Changchien L-M, Duceman B, Maley F, Plummer TH Jr (1990)J Biol Chem 265:6961–65.

    Google Scholar 

  106. Tarentino AL, Gomes CM, Plummer TH Jr (1985)Biochemistry 24:4665–71.

    Google Scholar 

  107. Tarentino AL, Plummer TH Jr (1987)Methods Enzymol 138:771–78.

    Google Scholar 

  108. Taga EM, Waheed A, Van Etten RL (1984)Biochemistry 23:815–22.

    Google Scholar 

  109. Barsomian GD, Johnson TL, Borowski M, Denman J, Ollington JF, Hirani S, McNeilly DS, Rasmussen JR (1990)J Biol Chem 265:6967–72.

    Google Scholar 

  110. Ogawa-Arakawa M, Muramatsu T, Kobata A (1977)J Biochem 82:611–14.

    Google Scholar 

  111. Li S-C, Asakawa M, Hirabayashi Y, Li Y-T (1981)Biochim Biophys Acta 660:278–83.

    Google Scholar 

  112. Hitomi J, Murakami Y, Saitoh F, Shigemitsu N, Yamaguchi H (1985)J Biochem 98:527–33.

    Google Scholar 

  113. Freeze H, Etchison JR (1984)Arch Biochem Biophys 232:414–21.

    Google Scholar 

  114. Tsuji Y, Yamamoto K, Tochikura T (1990)Appl Environ Microbiol 56:928–33.

    Google Scholar 

  115. Kadowaki S, Yamamoto K, Fujisaki M, Kumagai H, Tochikura T (1988)Agric Biol Chem 52:2387–89.

    Google Scholar 

  116. Kadowaki S, Yamamoto K, Fujisaki M, Izumi K, Tochikura T, Yokoyama T (1990)Agric Biol Chem 54:97–106.

    Google Scholar 

  117. Bouquelet S, Strecker G, Montreuil J, Spik G (1980)Biochemie 62:43–49.

    Google Scholar 

  118. Takegawa K, Nakoshi M, Iwahara S, Yamamoto K, Tochikura T (1989)Appl Environ Microbiol 55:3107–12.

    Google Scholar 

  119. Morinaga T, Kitamikado M, Iwase H, Li S-C, Li Y-T (1983)Biochim Biophys Acta 749:211–13.

    Google Scholar 

  120. Cohen RE, Zhang W-J, Ballou CE (1982)J Biol Chem 257:5730–37.

    Google Scholar 

  121. Ito S, Muramatsu T, Kobata A (1975)Arch Biochem Biophys 171:78–86.

    Google Scholar 

  122. Muramatsu T, Koide N, Maeyama K (1978)J Biochem 83:363–70.

    Google Scholar 

  123. Elder JH, Alexander S (1982)Proc Natl Acad Sci USA 79:4540–44.

    Google Scholar 

  124. Trimble RB, Tarentino AL (1991)J Biol Chem 266:1646–51.

    Google Scholar 

  125. Tarentino AL, Quinones G, Schrader WP, Changchien L-M, Plummer TH Jr (1992)J Biol Chem 267:3867–72.

    Google Scholar 

  126. Tarentino AL, Quinones G, Changchien L-M, Plummer TH Jr (1993)J Biol Chem 268:9702–8.

    Google Scholar 

  127. Yamamoto K, Kadowaki S, Takegawa K, Kumagai H, Tochikura T (1986)Agric Biol Chem 50:421–29.

    Google Scholar 

  128. Takegawa K, Mikami B, Iwahara S, Morita Y, Yamamoto K, Tochikura T (1991)Eur J Biochem 202:175–80.

    Google Scholar 

  129. Takegawa K, Naitoh T, Iwahara S (1991)Biochem Int 24:793–99.

    Google Scholar 

  130. Tarentino AL, Plummer TH Jr, Maley F (1972)J Biol Chem 247:2629–31.

    Google Scholar 

  131. Tarentino AL, Maley F (1974)J Biol Chem 249:811–17.

    Google Scholar 

  132. Trimble RB, Tarentino AL, Evans F, Maley F (1979)J Biol Chem 254:9705–13.

    Google Scholar 

  133. Robbins PW, Trimble RB, Wirth DF, Hering C, Maley F, Maley GF, Das R, Gibson BW, Royal N, Biemann K (1984)J Biol Chem 259:7577–83.

    Google Scholar 

  134. Ramakrishnan S, Eagle MR, Houston LL (1982)Biochim Biophys Acta 719:341–48.

    Google Scholar 

  135. Foxwell BMJ, Donovan TA, Thorpe PE, Wilson G (1985)Biochim Biophys Acta 840:193–203.

    Google Scholar 

  136. Kimura Y, Kusuoku H, Tada M, Takagi S, Funatsu G (1990)Agric Biol Chem 54:157–62.

    Google Scholar 

  137. Koide H, Itoh H, Kawauchi H (1993)Int J Peptide Prot Res 41:52–65.

    Google Scholar 

  138. Keller PJ, Kauffman DL, Allan BJ, Williams BL (1971)Biochemistry 10:4867–74.

    Google Scholar 

  139. Takahashi T, Schmidt PG, Tang J (1984)J Biol Chem 259:6059–62.

    Google Scholar 

  140. Takahashi T, Yonezawa S, Dehdarani AH, Tang J (1986)J Biol Chem 261:9368–74.

    Google Scholar 

  141. Hase S, Fujimura K, Kanoh M, Ikenaka T (1982)J Biochem 92:265–70.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 113, Tokyo, Japan

    Ken Kitajima & Yasuo Inoue

  2. School of Pharmaceutical Sciences, Showa University, 142, Tokyo, Japan

    Tadashi Suzuki & Sadako Inoue

Authors
  1. Tadashi Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ken Kitajima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sadako Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yasuo Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Suzuki, T., Kitajima, K., Inoue, S. et al. N-Glycosylation/deglycosylation as a mechanism for the post-translational modification/remodification of proteins. Glycoconjugate J 12, 183–193 (1995). https://doi.org/10.1007/BF00731318

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00731318

Keywords

Search

Navigation