Summary
18 female patients with primary depression received a slow intravenous infusion of amitriptyline and a good therapeutic response was observed in 15 patients as early as after 6 days. A highly significant correlation was found between improvement scores following the first and last infusions, which suggests that intravenous infusion of amitriptyline may serve as a prognostic test for prediction of drug efficacy. Total blood serotonin content prior to treatment was significantly lower than in normal controls. Amitriptyline infusion caused variable changes in blood serotonin and the changes were inversely correlated with pretreatment levels. A series of six infusions caused a gradual increase in baseline levels, together with a rapid decrease in the magnitude of the amitriptyline-induced changes in serotonin content.
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Banki, C.M.: Correlation of anxiety and related symptoms with CSF 5HIAA in depressed women. J. Neur. Transmiss.41, 136–143 (1977)
Berstad, J.: Total 5-hydroxyindoles in blood related to migraine attacks. Acta Neurol. scand.54, 293–300 (1976)
Carlsson, A., Corrodi, H., Fuxe, K.: Effect of antidepressant drugs on the depletion of intraneuronal brain 5HT caused by 4-methyl-γ-ethylmetatyramine. Europ. J. Pharmacol.5, 357–366 (1969)
Curzon, G., Green, A.R.: Rapid method for the determination of 5HT and 5HIAA in small regions of rat brain. Br. J. Pharmacol.39, 653–655 (1970)
Feighner, J., Robins, E., Guze, S.B.: Diagnostic criteria for use in psychiatric research. Arch. gen. Psychiatry26, 57–63 (1972)
Geeraerts, F., Schimpfessel, L., Crokaert, R.: A simple routine method to preserve and determine blood 5HT. Experientia30, 837–839 (1974)
Hamberger, B., Tuck, J.R.: Effect of tricyclic antidepressants on the uptake of norepinephrine and serotonin by rat brain slices incubated in buffer or plasma. Europ. J. clin. Pharmacol.5, 229–235 (1973)
Hamilton, M.: A rating scale for depression. J. Neurol. Neurosurg. Psychiatry23, 56–62 (1960)
Joseph, M.H., Baker, H.T.: The determination of 5HTP and its metabolites in plasma following administration in man. Clin. Chim. Acta72, 125–131 (1976)
Leger, J.M., Dumont, D.: L'action thérapeutique de l'amitriptyline en perfusion intraveineuse lente. Rev. Med. Limoges6, 187–194 (1975)
Maas, J.W.: Biogenic amines and depression. Arch. Gen. Psychiatry32, 1357–1361 (1975)
Mathematik und Statistik. Basel: Documenta Geigy 1975
Murphy, D.L.: Amine precursors, Amines and false transmitters in depression. Amer. J. Psychiatry129, 141–148 (1972)
Nyback, H.V., Walter, J.R., Aghajanian, G.K.: Tricyclic antidepressants: effect on the firing rate of brain noradrenergic neurons. Europ. J. Pharmacol.32, 302–312 (1975)
Pletscher, A.: Metabolism, transfer and storage of 5HT in blood platelets. Br. J. Pharmacol. Chemother.32, 1–16 (1968)
Ross, S.B., Renyi, A.L.: Inhibition of the uptake of tritiated 5HT in brain tissue. Europ. J. Pharmacol.7, 270–277 (1969)
Schildkraut, J.J., Dodge, G.A., Longe, M.A.: Effect of tricyclic antidepressants on the uptake and metabolism of intracisternally administered norepinephrine in rat brain. J. psychiatr. Res.7, 29–34 (1969)
Schubert, J., Nyback, H., Sedvall, G.: Effect of antidepressant drugs on the accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain. J. Pharm. Pharmacol.22, 136–138 (1970)
Strauss, H.W., Smith, R.B., Polimeni, P.: Plasma 5HT levels in stored human blood. Angiology18, 535–546 (1967)
Vojnik, M., Banki, C.M., Bardos, L.: Intravenous amitriptyline infusion in the treatment of depression. Ideggyógy. Szle, in press
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Banki, C.M., Vojnik, M. Effect of intravenous infusion of amitriptyline on total blood serotonin content. Eur J Clin Pharmacol 13, 259–262 (1978). https://doi.org/10.1007/BF00716360
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DOI: https://doi.org/10.1007/BF00716360