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Comparative mapping ofYRRM- andTSPY-related cosmids in man and hominoid apes

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Abstract

Using chromosomalin situ hybridization it has been demonstrated that specific members of theYRRM and theTSPY families are multicopy and Y chromosome specific in hominoids. After hybridization with theYRRM-related cosmid A5F and theTSPY-related cosmids cos36 and cY91, a reverse and complementary pattern of main and seconary signals is detected on the Y chromosomes of the human, the pygmy chimpanzee and the gorilla, while the location of signals coincides on the Y chromosomes of the chimpanzee, both orang-utan subspecies and the white hand gibbon. This complementary distribution ofYRRM andTSPY sequences on the hominoid Y chromosomes possibly originates from a similar sequence motif that is shared by and evolutionarily conserved between certain members of both gene families and/or repeated elements flanking those genes. Otherwise this complementary distribution could go back to a common organization of these genes next to each other on an ancient Y chromosome which was disrupted by chromosomal rearrangements and amplification of one or other of the genes at each of the locations.

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References

  • Arnemann J, Epplen JT, Cooke HJet al. (1987) A human Y-chromosomal DNA sequence expressed in testicular tissue.Nucleic Acids Res 15: 8713–8724.

    Google Scholar 

  • Arnemann J, Jakubiczka S, Thüring S, Schmidtke J (1991) Cloning and sequence analysis of a human Y chromosome-derived, testicular cDNA, TSPY.Genomics 11: 108–114.

    Google Scholar 

  • Berta P, Hawkins JR, Sinclair AHet al. (1990) Genetic evidence equating SRY and the testis-determining factor.Nature 348: 448–450.

    Google Scholar 

  • Chandley AC, Gosden JR, Hargreave TBet al. (1989) Deleted Yq in the sterile son of a man with a satellited Y chromosome (Yqs).J Med Genet 26: 145–153.

    Google Scholar 

  • Fau Y-S, Davis LM, Shows TB (1990) Mapping small DNA sequences by fluorescencein situ hybridization directly on banded metaphase chromosomes.Proc Natl Acad Sci USA 87: 6223–6227.

    Google Scholar 

  • Guttenbach M, Müller U, Schmid M (1992) A human moderately repeated Y-specific DNA sequence is evolutionarily conserved in the Y chromosome of the great apes.Genomics 13: 363–367.

    Google Scholar 

  • Jäger RJ, Anvret M, Hall K, Scherer G (1990) A human XY female with a frame shift mutation in the candidate testisdetermining gene SRY.Nature 348: 452–454.

    Google Scholar 

  • Jakubiczka S, Schnieders F, Schmidtke J (1993) A bovine homologue of the human TSPY gene.Genomics 17: 732–735.

    Google Scholar 

  • Jauch A, Wienberg J, Stanyon Ret al. (1992) Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.Proc Natl Acad Sci USA 89: 8611–8615.

    Google Scholar 

  • Kunkel LM, Smith KD, Boyer SHet al. (1977) Analysis of human Y chromosome specific reiterated DNA in chromosome variants.Proc Natl Acad Sci USA 74: 1245–1249.

    Google Scholar 

  • Lichter P, Cremer T, Borden J, Manuelidis L, Ward DD (1988) Delineation of individual human chromosomes in metaphases and interphase cells byin situ suppression hybridization using recombinant DNA libraries.Hum Genet 80: 224–234.

    Google Scholar 

  • Ma K, Sharkey A, Kirsch Set al. (1992) Towards the molecular localization of the AZF locus: mapping of microdeletions in azoospermic men within 14 subintervals of interval 6 of the human Y chromsome.Hum Mol Genet 1: 29–33.

    Google Scholar 

  • Ma K, Inglis JD, Sharkey Aet al. (1993) A Y chromosome gene family with RAN-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.Cell 75: 1287–1295.

    Google Scholar 

  • Manz E, Schnieders F, Müller Brechlin A, Schmidtke J (1993) TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome.Genomics 17: 726–731.

    Google Scholar 

  • Miller DA (1977) Evolution of primate chromosomes. Man's closest relative may be the gorilla, not the chimpanzee.Science 198: 1116–1124.

    Google Scholar 

  • Müller G, Schempp W (1991) Comparative mapping of ZFY in the hominoid apes.Hum Genet 88: 59–63.

    Google Scholar 

  • Pinkel D, Gray JW, Trask Bet al. (1986) Cytogenetic analysis byin situ hybridization with fluorescently labelled nucleic acid probes.Cold Spring Harbor Symp Quant Biol 51: 151–157.

    Google Scholar 

  • Schempp W, Meer B (1983) Cytologic evidence for three human X-chromosomal segments escaping inactivation.Hum Genet 63: 171–174.

    Google Scholar 

  • Schempp W, Toder R, Rietschel W, Grützner F, Mayerová A, Gauckler A (1993) Inverted and satellited Y chromosome in the orangutan (Pongo pygmaeus).Chrom Res 1: 69–75.

    Google Scholar 

  • Schiebel K, Weiss B, Wöhrle D, Rappold GA (1993) A human pseudoautosomal gene. ADP/ATP translocase, escapes X-inactivation whereas a homologue on Xq is subject to X-inactivation.Nature Genet 3: 82–87.

    Google Scholar 

  • Sinclair AH, Berta P, Palmer MSet al. (1990) A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif.Nature 346: 240–244.

    Google Scholar 

  • Taylor K, Ulinowski Z, Wolfe J (1991) Contig assembly of cosmid clones from the Y chromosome.Cytogenet Cell Genet 58: 2096.

    Google Scholar 

  • Tiepolo L, Zuffardi O (1976) Localization of the factors controlling spermatogenesis in the nonfluorescent portion of the Y chromosome long arm.Hum Genet 34: 119–124.

    Google Scholar 

  • Toder R, Zeitler S, Goodfellow PN, Schempp W (1993) Comparative mapping of SRY in the great apes.Chrom Res 1: 117–120.

    Google Scholar 

  • Tyler-Smith C, Taylor L, Müller U (1988) Structure of a hypervariable tandemly repeated DNA sequence on the short arm of the human Y chromosome.J Mol Biol 203: 837–848.

    Google Scholar 

  • Weber B, Schempp W, Wiesner H (1986) An evolutionarily conserved early replicating segment on the sex chromosomes of the great apes.Cytogenet Cell Genet 43: 72–78.

    Google Scholar 

  • Weber B, Weissenbach J, Schempp W (1987) Conservation of human-derived pseudoautosomal sequences on the sex chromosomes of the great apes.Cytogenet Cell Genet 45: 26–29.

    Google Scholar 

  • Weber B, Weissenbach J, Schempp W (1988) X-Y crossing over in the chimpanzee.Hum Genet 80: 301–303.

    Google Scholar 

  • Weissenbach J, Goodfellow PN, Smith KD (1989) Report of the committee on the genetic constitution of the Y chromosome.Cytogenet Cell Genet 51: 438–449.

    Google Scholar 

  • Yunis JJ, Prakash O (1982) The origin of man; a chromosomal pictorial legacy.Science 215: 1525–1530.

    Google Scholar 

  • Zhang JS, Yang-Feng TL, Müller Uet al. (1992) Molecular isolation and characterization of an expressed gene from the human Y chromosome.Hum Mol Genet 1: 717–726.

    Google Scholar 

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Authors and Affiliations

  1. the Institute of Human Genetics and Anthropology, University of Freiburg, Breisacher Straße 33, D-79106, Freiburg, Germany

    Werner Schempp, Andreas Binkele, Birgitta Gläser, Roland Toder & Sylvia Zeitler

  2. the MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK

    Kun Ma & Ann C. Chandley

  3. the Institute of Human Genetics, University of Frankfurt a.M., Theodor-Stern-Kai, Frankfurt, Germany

    Joachim Arnemann

  4. The Galton Laboratory, University College London, Wolfson House, NW1 2HE, London, UK

    Kay Taylor & Jonathan Wolfe

Authors
  1. Werner Schempp
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  2. Andreas Binkele
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  3. Joachim Arnemann
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  4. Birgitta Gläser
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  5. Kun Ma
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  6. Kay Taylor
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  7. Roland Toder
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  8. Jonathan Wolfe
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  9. Sylvia Zeitler
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  10. Ann C. Chandley
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Schempp, W., Binkele, A., Arnemann, J. et al. Comparative mapping ofYRRM- andTSPY-related cosmids in man and hominoid apes. Chromosome Res 3, 227–234 (1995). https://doi.org/10.1007/BF00713047

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  • DOI: https://doi.org/10.1007/BF00713047

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