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Stable isotope dilution analysis of GABA in CSF using simple solvent extraction and electron-capture negative-ion mass fragmentography

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Journal of Inherited Metabolic Disease

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References

  • Carchon HA, Jaeken J, Jansen E, Eggermont E (1991) Reference values for free gamma-aminobutyric acid determined by ion-exchange chromatography and fluorescence detection in the cerebrospinal fluid of children.Clin Chim Acta 201: 83–88.

    Google Scholar 

  • Enna SJ, Wood JH, Snijder SH (1977) γ-Aminobutyric acid (GABA) in human cerebrospinal fluid: radioreceptor assay.J Neurochem 28: 1121–1124.

    Google Scholar 

  • Goldsmith RF, Earl JW, Cunningham AM (1987) Determination of gamma-aminobutyric acid and other amino acids in cerebrospinal fluid of pediatric patients by reversed phase liquid chromatography.Clin Chem 33: 1736–1740.

    Google Scholar 

  • Grove J, Schechter PJ, Tell G et al (1982) Artifactual increases in the concentration of free GABA in samples of human cerebrospinal fluid are due to degradation of homocarnosine.J Neurochem 39: 1061–1065.

    Google Scholar 

  • Haan EA, Brown GK, Mitchell D, Danks DM (1985) Succinic semialdehyde dehydrogenase deficiency — a further case.J Inher Metab Dis 8: 99.

    Google Scholar 

  • Howells DW, Jakobs C, Kok RM, Wrennall J, Thompson GN (1992) Vigabatrin therapy in succinic semialdehyde dehydrogenase deficiency.Mol Neuropharmacol 2: 181–184.

    Google Scholar 

  • Huizinga JD, Teelken AW, Muskiet FAJ, Jeuring HJ, Wolthers BG (1978) Gamma-aminobutyric acid determination in human cerebrospinal fluid by mass fragmentography.J Neurochem 30: 911–913.

    Google Scholar 

  • Jaeken J, Casear P, Haegele KD, Schechter PJ (1990) Review: Normal and abnormal central nervous system GABA metabolism in childhood.J Inher Metab Dis 13: 793–801.

    Google Scholar 

  • Jakobs C, Jaeken J, Gibson KM (1993) Inherited disorders in GABA metabolism.J Inher Metab Dis 16(4), in press.

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Authors and Affiliations

  1. Department of Pediatrics, Free University Hospital, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    R. M. Kok, C. C. M. van den Heuvel, W. S. Guérand & C. Jakobs

  2. Department of Neurology, Austin Hospital, University of Melbourne, Heidelberg, Australia

    D. W. Howells

  3. The Murdoch Institute, Royal Childrens Hospital, Melbourne, Australia

    G. N. Thompson

Authors
  1. R. M. Kok
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  2. D. W. Howells
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  3. C. C. M. van den Heuvel
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  4. W. S. Guérand
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  5. G. N. Thompson
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  6. C. Jakobs
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Kok, R.M., Howells, D.W., van den Heuvel, C.C.M. et al. Stable isotope dilution analysis of GABA in CSF using simple solvent extraction and electron-capture negative-ion mass fragmentography. J Inherit Metab Dis 16, 508–512 (1993). https://doi.org/10.1007/BF00711667

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  • DOI: https://doi.org/10.1007/BF00711667

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