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Selective effects of human immunodeficiency virus (HIV) gp120 on invertebrate neurons

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Summary

  1. 1.

    HIV gp120 selectively reduces the glutamate-induced inward current and the acetylcholine-induced outward current in specific and identifiedAplysia neurons without affecting dopamine (DA)- and serotonin (5-HT)-induced responses.

  2. 2.

    gp120 specifically decreases DA levels without significantly altering norepinephrine and 5-HT levels inMytilus pedal ganglia.

  3. 3.

    The gp120-associated decrease in DA levels inMytilus is dose dependent and exhibits a threshold level.

  4. 4.

    The alteration ofin vitro DA levels is specific for gp120 since anti-gp120 blocks the effect.

  5. 5.

    gp120 and its effects appear to be stable due to the duration of treatment and the failure of secondary effects to materialize following antibody treatment.

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References

  • Brenneman, D., Westbrook, G., Fitzgerald, S., Ennist, D., Elkins, K., Ruff, M., and Pert, C. (1988). Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide.Nature 335639–642.

    Google Scholar 

  • da Cunha, A., and Eiden, L. E. (1993). Neuro-Aids: Primate lentivirus infection and the brain.Adv. Neuroimmunol. 3(2):55–85.

    Google Scholar 

  • Dreyer, E., Kaiser, P., Offerman, J., and Lipton, S. (1990). HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists.Science 248364–367.

    Google Scholar 

  • Everall, I. P., Luthert, P. J., and Lantos, P. L. (1991). Neuronal loss in the frontal cortex in HIVG infection.Lancet 3371119–1121.

    Google Scholar 

  • Gabuzda, D., and Hirsch, M. (1987). Neurologic manifestations of infections with human deficiency virus. Clinical features and pathogenesis.Ann. Intern. Med. 107383–391.

    Google Scholar 

  • Harouse, J., Bhat, S., Spitalnik, S., Laughlin, M., Stefano, K., Silberberg, D., and Gonzalez-Scarano, F. (1991). Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide.Science 253320–323.

    Google Scholar 

  • Hart, T. K., Kirsch, R., Ellens, H., Sweets, R., Lambert, D., Petteway, S., Leary, J., and Bugelsky, T. J. (1991). Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.Proc. Natl. Acad. Sci. 882189–2193.

    Google Scholar 

  • Hughes, T. K., Jr., Smith, E. M., Cadet, P., Sinisterra, J., Leung, M. K., Shipp, M. A., Scharrer, B., and Stefano, G. B. (1990). Interaction of immunoactive monokines (IL-1 and TNF) in the bivalve mollusc Mytilus edulis.Proc. Natl. Acad. Sci. USA 874426–4429.

    Google Scholar 

  • Hughes, T. K., Smith, E. M., Barnett, J. A., Charles, R., and Stefano, G. B., (1991a). LPS stimulated invertebrate hemocytes: A role for immunoreactive TNF and IL-1.Dev. Comp. Immunol. 15117–122.

    Google Scholar 

  • Hughes, T. K., Smith, E. M., Barnett, J. A., Charles, R., and Stefano, G. B. (1991b). LPS and opioids activate distinct populations of Mytilus edulis immunocytes.Cell Tissve Res. 264317–320.

    Google Scholar 

  • Hughes, T. K., Smith, E. R., Leung, M. K., and Stefano, G. B. (1992). Evidence for the conservation of an immunoreactive monokine network in invertebrates. In.Ontogenetic and Phylogenetic Mechanisms of Neuroimmunomodulation (N. Fabris, B. D. Jankovic, B. M. Markovic, and N. H. Spector, Eds.), Ann. N.Y. Acad. Sci. Vol. 650, pp. 75-81.

  • Kaiser, P., Offerman, J., and Lipton, S. (1990). Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies.Neurology 401757–1761.

    Google Scholar 

  • Kent, T. A., Hillman, G. R., Levin, H. S., Guinto, F., Kaye, A. R., and Casper, K. (1993). Neuroimaging in HIV infection: A preliminary quantitative MRI study and review of the literatureAdv.Neuroimmunol. 317–28.

    Google Scholar 

  • Ketzler, S., Weiss, S., Huag, H., and Budka, H., (1990). Loss of neurons in the frontal cortex of AIDS brains.Acta Neuropathol. (Berlin)8092–94.

    Google Scholar 

  • Koenig, S., Gendelman, J., Orenstein, J., Dalcanto, M., Pezeshkpour, G., Yungbluth, M., Jannotta, F., Aksamit, A., Martin, M., and Fauci, A. (1986). Detection of AIDs virus in macrophages in brain tissue from AIDS patients with encephalopathy.Science 2331089–1093.

    Google Scholar 

  • Leung, M. K., Le, S., Houston, S., and Stefano, G. B. (1992). Degradation of Met-enkephalin by hemolymph peptidases inMytilus edulis.Cell. Mol. Neurobiol. 12367–378.

    Google Scholar 

  • Lipton, S., Kaiser, P., Offerman, J., and Dreyer, B. (1990). HIV-1 coat protein gp120 increases intracellular CA2+ and injures central neurons: Toxicity prevented by CA2+ channel antagonists.Neurology 40 (Suppl. 1):273.

    Google Scholar 

  • Lipton, S., Sucher, N., Kaiser, P., and Dreyer, E., (1991). NMDA antagonists prevent neurotoxicity from HIV coat protein gp120.Neurology 41(Suppl. 1):198.

    Google Scholar 

  • Masliah, E., Ge, N., Morey, M., DeTeresa, R., Terry, R. D., and Wiley, C. A. (1992). Cortical dendritic pathology in human immunodeficiency virus encephalitis.Lab. Invest. 66285–291.

    Google Scholar 

  • Merrill, J., (1993). Cytokines and HIV-1 in neural-immune interactions.Adv. Neuroimmunol. 317–30.

    Google Scholar 

  • Merrill, J., Koyanagi, Y., Zack, J., Thomas, L., Martin, F., and Chen, I. (1992). Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type I.J. Virol. 662217–2225.

    Google Scholar 

  • Paemen, L. R., Porchet-Hennere, E., Masson, M., Leung, M. K., Hughes, T. K., and Stefano, G. B., (1992). Glial localization of interleukin-la in invertebrate ganglia.Cell. Mol. Neurobiol. 12463–472.

    Google Scholar 

  • Rao, C., Anzil, A. P., and Sher, J. H. (1993). The neuropathology of AIDS: a review.Adv. Neuroimmunol. 31–16.

    Google Scholar 

  • Sawada, M., Hara, N., and Maeno, T. (1991). Ionic mechanism of the outward current induced by extracellular ejection of interleukin-1 onto identified neurons of Aplysia.Brain Res. 545248–256.

    Google Scholar 

  • Sawada, M., Enomoto, K., Maeno, T., and Blankenship, J. E. (1980). Ionic mechanisms of inhibition of long duration inAplysia synapse.J. Neurosci. Res. 5537–553.

    Google Scholar 

  • Stefano, G. B. (1992). Invertebrate and vertebrate immune and nervous system signal molecule commonalties.Cell. Mol. Neurobiol. 12357–366.

    Google Scholar 

  • Stefano, G. B., and Catapane, E. J., (1980). Norepinephrine: Its presence in the C.N.S. of the bivalve mollusc,Mytilus edulis.J. Exp. Zool. 214209–213.

    Google Scholar 

  • Stefano, G. B., Zhao, X., Bailey, D., Metlay, M., and Leung, M. K. (1989). High affinity dopamine binding to mouse thymocytes and Mytilus edulis (Bivalvia) hemocytes. J. Neuroimmunol.21(1):67–74.

    Google Scholar 

  • Stefano, G. B., Smith, E. M., Paemen, R. R., and Hughes, T. K. (1993a). HIV GP120 associated neurological deficits: A potential role for nitric oxide and other signal molecules.Adv. Neuroimmunol. 347–58.

    Google Scholar 

  • Stefano, G. B., Smith, E. M., Cadet, P., and Hughes, T. K. (1993b). HIV GP120 alteration of DAMA and IL-1a induced chemotaxic responses in human and invertegrate immunocytes.J. Neuroimmunol. 43177–184.

    Google Scholar 

  • Stefano, G. B., Bilfinger, T. V., and Fricchione, G. L. (1994). The immune-neuro-link and the macrophage: Postcardiotomy delirium, HIV-associated dementia and psychiatry.Prog. Neurobiol. (in press).

  • Szûcs, A., Stefano, G. B., Hughes, T. K., and S.-Rózsa, K. (1992). Modulation of voltage-activated ion currents on identified neurons of Helix pomatia L. by interleukin-1.Cell Mol. Neurobiol. 12429–438.

    Google Scholar 

  • Wiley, C., Schreier, R., Nelson, J., Lampert, P., and Oldstone, M. (1986). Cellular localization of human immunodeficiency virus infection within the brains of acquired immunodeficiency syndrome patients.Proc. Natl. Acad. Sci. USA 837089–7093.

    Google Scholar 

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Authors and Affiliations

  1. Old Westbury Neuroscience Research Institute, State University of New York at Old Westbury, 11568-0210, Old Westbury, New York, USA

    G. B. Stefano

  2. Department of Physiology, Shimane Medical University, Izumo, Japan

    M. Sawada

  3. Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 77550, Galveston, Texas, USA

    E. M. Smith

  4. Department of Microbiology, University of Texas Medical Branch, 77550, Galveston, Texas, USA

    T. K. Hughes

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  1. G. B. Stefano
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  2. M. Sawada
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  3. E. M. Smith
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  4. T. K. Hughes
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Stefano, G.B., Sawada, M., Smith, E.M. et al. Selective effects of human immunodeficiency virus (HIV) gp120 on invertebrate neurons. Cell Mol Neurobiol 13, 569–577 (1993). https://doi.org/10.1007/BF00711557

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  • DOI: https://doi.org/10.1007/BF00711557

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