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The effect of lovastatin on very low-density lipoprotein apolipoprotein B production by the liver in familial combined hyperlipidaemia

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Journal of Inherited Metabolic Disease

Summary

Overproduction of very low-density lipoprotein apolipoprotein B by the liver is a metabolic marker for familial combined hyperlipidaemia, a common inherited disorder of lipoprotein metabolism. Four subjects with familial combined hyperlipidaemia had rates of apolipoprotein B production which were 2–7 times normal, using a protocol in which [15N]nglycine was used to label newly synthesized hepatic proteins. Following 4–6 months of therapy with lovastatin, very low-density lipoprotein apolipoprotein B production in all four subjects had returned to the normal range. This demonstrates that lovastatin, an inhibitor of cholesterol biosynthesis, acts also to reduce the apparent production rate of apolipoprotein B by the liver.

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Authors and Affiliations

  1. Lipid-Heart Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    J. A. Cortner & P. M. Coates

  2. Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    J. A. Cortner & P. M. Coates

  3. Metabolic Disease Center, Baylor University Medical Center, Dallas, Texas, USA

    M. J. Bennett

  4. Division of Arteriosclerosis and Lipid Metabolism, Department of Medicine, Emory University, Atlanta, Georgia, USA

    N. -A. Le

Authors
  1. J. A. Cortner
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  2. M. J. Bennett
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  3. N. -A. Le
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  4. P. M. Coates
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Cortner, J.A., Bennett, M.J., Le, N.A. et al. The effect of lovastatin on very low-density lipoprotein apolipoprotein B production by the liver in familial combined hyperlipidaemia. J Inherit Metab Dis 16, 127–134 (1993). https://doi.org/10.1007/BF00711326

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  • DOI: https://doi.org/10.1007/BF00711326

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