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Pleomorphic adenomas, adenoid cystic carcinomas and adenolymphomas of salivary glands analysed by a monoclonal antibody against myoepithelial/basal cells

An immunohistochemical study

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Summary

Myoepithelial and basal cells were identified by a monoclonal antibody raised against keratin. This antibody (CK B1) which detects myoepithelial cells in normal salivary glands, labels spindle shaped and polygonal cells in pleomorphic adenomas. Most cells in adenoid cystic carcinomas and some basal cells in adenolymphomas were also positive for this antibody. The oncocytic epithelium of adenolymphoma was negative.

An inverse reaction was seen with an antibody against cytokeratin 18.

The antibody CK B1 seems to be of interest for the detection of myoepithelial/basal cells in salivary glands and salivary gland tumours.

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Authors and Affiliations

  1. Institute of Pathology, University of Hamburg, Martinistrasse 52, D-2000, Hamburg

    J. Caselitz & K. Hamper

  2. Max-Planck-Institute of Biophysical Chemistry, D-3400, Göttingen

    M. Osborn & K. Weber

  3. Ear-, Nose and Throat Clinics, University of Kiel, D-2300, Kiel

    J. Wustrow

  4. Ear-, Nose und Throat Clinics, University of Hamburg, D-2000, Hamburg, Federal Republic of Germany

    A. Rauchfuß

Authors
  1. J. Caselitz
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  2. M. Osborn
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  3. K. Hamper
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  4. J. Wustrow
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  5. A. Rauchfuß
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  6. K. Weber
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Dedicated to Prof. Dr. G. Seifert on the occasion of his 65th birthday

Supported by the Deutsche Forschungsgemeinschaft and by the Hamburger Stiftung zur Förderung der Krebsbekämpfung

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Caselitz, J., Osborn, M., Hamper, K. et al. Pleomorphic adenomas, adenoid cystic carcinomas and adenolymphomas of salivary glands analysed by a monoclonal antibody against myoepithelial/basal cells. Vichows Archiv A Pathol Anat 409, 805–816 (1986). https://doi.org/10.1007/BF00710765

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  • DOI: https://doi.org/10.1007/BF00710765

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