Summary
The histological grades of prostatic carcinoma, as defined by Gleason, were correlated with three methods of morphometry in 254 step-sectioned prostates obtained at autopsy. The variables studied were 1) the number of tumours in each prostate; 2) bilaterality and 3) tumour volume. Each characteristic yielded a statistically significant correlation with histological grade. The strongest correlations were obtained using tumour volume. These autopsy studied help to explain the inconsistent results obtained from morphometric analyses of surgical material, and lend support to the Gleason system as a means of predicting tumour behavior.
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Supported in part by research contracts PH 64-10, NCI-72-3213, N01-CP-53521; Grant R01-CA-33644; and the Grant-in-Aid for Cancer Research (33) from the Ministry of Health and Welfare
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Yatani, R., Shiraishi, T., Akazaki, K. et al. Incidental prostatic carcinoma: Morphometry correlated with histological grade. Vichows Archiv A Pathol Anat 409, 395–405 (1986). https://doi.org/10.1007/BF00705412
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DOI: https://doi.org/10.1007/BF00705412