Summary
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1.
The antipruritic ability of histamine (H1 and H2) antagonists alone and in combination in experimentally induced pruritus has been investigated in 12 normal human volunteers.
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2.
A combination of cimetidine (H2 antagonist) and chlorpheniramine (H1 antagonist) proved effective in suppressing itch that was artificially induced by the application of papain and histamine.
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3.
The combination was more effective than chlorpheniramine or cimetidine alone or placebo.
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4.
The results suggest that both H1 and H2 receptors are involved in the mediation of pruritus.
Zusammenfassung
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1.
Die antipruriginöse Wirksamkeit von Histaminantagonisten (H1 und H2) alleine und im Kombination wurden bei experimentell induzierten Juckreiz bei 12 gesunden Freiwilligen untersucht.
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2.
Die Kombination von Cimetidin (H2-Antagonist) und Chlorpheniramin (H1-Antagonist) zeigte sich als wirksam in der Form, daß Juckreiz, welcher durch Applikåtion von Papain und Histamin intraepidermal sich entwickelt, unterdrückt wurde.
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3.
Die Kombination war wirksamer als Chlorpheniramin oder Cimetidin alleine gegeben bzw. gegenüber einem Placebo.
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4.
Diese Resultate lassen die Annahme zu, daß H1 und H2-Rezeptoren in der Auslösung des Juckreizes beteiligt sind.
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Davies, M.G., Marks, R., Horton, R.J. et al. The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus. Arch Dermatol Res 266, 117–120 (1979). https://doi.org/10.1007/BF00694619
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DOI: https://doi.org/10.1007/BF00694619