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Development of urine concentrating ability in pouch young of a marsupial, the tammar wallaby (Macropus eugenii)

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Summary

During the first 28–30 weeks after birth, pouch young of the tammar wallaby (Macropus eugenii) normally produce urine less than 500 mOsm/kg and elevate their urine concentration by less than 20% when dehydrated by about 10% of body weight. The adult tammar, in contrast, can produce urine in excess of 3,000 mOsm/kg. The aim of this study was to determine when the various processes involved in urine concentration become mature in the tammar.

Vasopressin was detectable in the pituitary of week-old tammars and pituitary vasopressin content decreased significantly after dehydration. Plasma vasopressin did not vary with age and dehydration was associated with an increase in plasma vasopressin levels. By 15 weeks of age at least, tammar kidney slices were able to bind vasopressin as indicated by a rise in tissue cAMP level following hormone treatment.

The sodium and urea content of the renal medulla increased with age and significant gradients of these solutes were established by 25 weeks of age. Pouch young older than 25 weeks showed increased medullary sodium and urea levels following dehydration.

The inability of pouch young less than 20 weeks of age to produce a highly concentrated urine does not result from any inadequacy in perception of osmotic stimuli or release of vasopressin by the pituitary or of binding of hormone by the kidney. Rather, it appears to be largely attributable to an insufficient medullary hypertonicity, particularly with respect to urea, which is consequent upon structural immaturity of the loop of Henle.

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Abbreviations

cAMP :

cyclic AMP adenosine 3′,5′-monophosphate

AVP :

arginine vasopressin

LVP :

lysine vasopressin

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Authors and Affiliations

  1. Department of Zoology, Australian National University, Canberra, A.C.T., Australia

    Gail E. Wilkes & Peter A. Janssens

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  1. Gail E. Wilkes
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  2. Peter A. Janssens
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Wilkes, G.E., Janssens, P.A. Development of urine concentrating ability in pouch young of a marsupial, the tammar wallaby (Macropus eugenii). J Comp Physiol B 156, 573–582 (1986). https://doi.org/10.1007/BF00691044

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