Abstract
Rats were injected with haloperidol (0.5–1.0 mg · kg−1). When the catalepsy score was almost maximal (60 s, measured by the bar-test), the rats were handled, exposed to cold (3° C) or immobilized. After each of these stress procedures the catalepsy was significantly reduced. Handling of adrenalectomized rats gave no such reduction. Infusion of adrenaline (10 nmol·kg−1, given in 15 s), in contrast to that of isoprenaline and phenylephrine (both the same concentration as adrenaline) also reduced the haloperidol induced catalepsy. These findings indicate that neuroleptic catalepsy in rats is not only mediated through central but also through peripheral mechanisms, e.g. by the adrenal medulla.
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References
Asper A, Bagglioni M, Burki HR, Lauener H, Ruck W, Stille G (1973) Tolerance phenomena with neuroleptics catalepsy, apomorphine stereo typies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidol. Eur J Pharmacol 22:287–294
Axelrod J, Reisine TD (1984) Stress hormones: their interaction and regulation. Science 224:452–459
Birkmayer W, Riederer P (1983) The clinical pathology of Parkinson's disease. In: Birkmayer W, Reiderer P (eds) Parkinson's disease. Springer, Wien New York, pp 46–88
Costall B, Olley JE (1971) Cholinergic- and neuroleptic-induced catalepsy: modification by lesions in the caudate-putamen. Neuropharmacology 10:297–306
Costall B, Naylor RJ (1979) Behavioural aspects of dopamine agonists and antagonists. In: Horn AS, Korf J, Westerink BHC (eds) The neurobiology of dopamine. Academic, London, pp 555–576
De Graaf CJ, Korf J (1986) Conditional tolerance to haloperidol induced catalepsy is not caused by striatal dopamine receptor supersensitivity. Psychopharmacology 90:54–57
Den Hartog-Jager WA (1970) Histochemistry of adrenal bodies in Parkinson's disease. Arch Neurol 23:528–533
Ezrin-Waters C, Seeman P (1979) Tolerance to haloperidol catalepsy. Eur J Pharmacol 41:321–327
Fog R (1972) On stereotypy and catalepsy: studies on the effects of amphetamines and neuroleptics in rats. Acta Neurol Scand, Suppl 50:3–66
Hartgraves SL, Kelly PH (1984) Role of mesencephalic reticular formation in cholinergic — induced catalepsy and anticholinergic reversal of neuroleptic — induced catalepsy. Brain Res 307:47–54
Hornykiewicz O (1979) Brain dopamine in Parkinson's disease and other neurological disturbances. In: Horn AS, Korf J, Westerink BMC (eds) The neurobiology of dopamine. Academic, London, pp 633–655
Jarkowski J (1925) Kinésie paradoxale des parkinsoniens. Paris, Marson Koda LY, Gibb JW (1972) Adrenal and striatal tyrosine hydroxylase activity after metamphetamine. J Pharmacol Exp Ther 185:42–48
Morelli M, Porceddu ML, Imperato A, Di Chiara G (1981) Role of substantia nigra pars reticulata neurons in the expression of neuroleptic-induced catalepsy. Brain Res 217:375–379
Poulos CX, Hinson R (1982) Pavlovian conditional tolerance to haloperidol catalepsy: evidence of dynamic adaptation in the dopaminergic system. Science 218:491–492
Puri SK, Lal M (1974) Tolerance to the behavioural and neurochemical effects of haloperidol and morphine in rats chronically treated with morphine or haloperidol. Naunyn Schmiedeberg's Arch Pharmacol 282:155–170
Quik M, Sourkes TL (1976) Central dopaminergic and serotoninergic systems in the regulation of adrenal tyrosine hydroxylase. J Neurochem 28:137–147
Riederer P, Rausch WD, Birkmayer W, Jellinger K, Seemann D (1978) CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic Encephalopathies. J Neural Transm [Suppl] 14:121–131
Sanberg PR (1980) Haloperidol-induced catalepsy is mediated by postsynaptic dopamine receptors. Nature 284:472–473
Siegel S (1956) Non-parametrical statistics for behavioural sciences. McGraw Hill, Tokyo, pp 116–127
Snyder AM, Stricker EM, Zigmond MJ (1985) Stress induced neurological impairements in an animal model of parkinsonism. Ann Neurol 18:544–551
Sourkes TL (1985) Neurotransmitters and central regulation of adrenal functions. Biol Psychiatry 20:182–191
Worms P, Willigens MT, Coutinsoara-Blanc D, Lloyd KG (1985) The effect of different types of cortical lesions on drug-induced catalepsy in rats: A pharmacological analysis. Eur J Pharmacol 113:53
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Yntema, O.P., Korf, J. Transient supression by stress of haloperidol induced catalepsy by the activation of the adrenal medulla. Psychopharmacologia 91, 131–134 (1987). https://doi.org/10.1007/BF00690942
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DOI: https://doi.org/10.1007/BF00690942