Abstract
The effects of lithium on psychomotor performance were examined in six healthy male volunteers (aged 26–31 years) and compared with those of a similar control population. Three computerised psychomotor tests (serial reaction time, semantic reasoning and syntatic reasoning) were administered before lithium, after 5 and 22 days of lithium carbonate (800 mg/d) and 4 days and 1 month after stopping the lithium. The only significant effect was an impairment of semantic reasoning during the chronic (22 day) test. This suggests a selective effect of lithium on associative mental tasks and may explain the subjects' experience of slowing in recall of object names whilst taking lithium.
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Glue, P.W., Nutt, D.J., Cowen, P.J. et al. Selective effect of lithium on cognitive performance in man. Psychopharmacologia 91, 109–111 (1987). https://doi.org/10.1007/BF00690937
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DOI: https://doi.org/10.1007/BF00690937