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Hypersensitivity and cross-reactivity to cisplatin and analogues

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  • Hypersensitivity, Cross-Reactivity, Cisplatin, Analogues
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Abstract

We report on a 49-year-old woman with relapsing ovarian cancer who developed a hypersensitivity reaction (HSR) to carboplatin and, subsequently, to cisplatin. This patient was known to be allergic to Co-Amoxiclav and talc, both giving rise to a transient macular skin rash, but had no other history of atopy. Similar cases, including some of life-threatening severity, have been reported in the literature. These severe reactions may prevent a small population of young patients from receiving effective therapy with cisplatin or its analogues, treatment known to be associated with a significant improvement in survival in germ-cell tumours, ovarian cancer and osteogenic sarcoma.

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Authors and Affiliations

  1. Department of Haematology, Glasgow Royal Infirmary, Castle Street, G4 OSF, Glasgow, UK

    A. A. Shlebak

  2. Clatterbridge Centre for Oncology, Clatterbridge Rd, L63 4JY, Bebington Wirral, UK

    P. I. Clark & J. A. Green

Authors
  1. A. A. Shlebak
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  2. P. I. Clark
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  3. J. A. Green
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Shlebak, A.A., Clark, P.I. & Green, J.A. Hypersensitivity and cross-reactivity to cisplatin and analogues. Cancer Chemother. Pharmacol. 35, 349–351 (1995). https://doi.org/10.1007/BF00689458

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  • DOI: https://doi.org/10.1007/BF00689458

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