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Effectiveness of Lipiodol in transcatheter arterial embolization of hepatocellular carcinoma

  • Session II: Treatment for Inoperable Patients TACE, Infusion Reservoir and Radiotherapy
  • Hepatocellular Carcinoma, Transcatheter Arterial Embolization, Lipiodol (Iodized oil)
  • Published:
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Summary

The effectiveness of Lipiodol (iodized oil) in transcatheter arterial embolization (TAE) of hepatocellular carcinoma (HCC) was retrospectively evaluated using statistical analysis. A total of 343 HCC patients who underwent TAE at 5 institutions between 1984 and 1989 were divided into 2 groups: the GS-TAE group underwent TAE with Gelfoam sponge alone, whereas the LP-TAE group was given Lipiodol (LP) immediately before GS-TAE. The statisticalT value calculated for the LP-TAE group showed that the administration of LP, the tumor size, intrahepatic metastasis, portal vein infiltration, and serum total bilirubin and alpha-fetoprotein levels significantly (P<0.01) affected the patients' survival. Both the cumulative survival determined using the Kaplan-Meier model and the cumulative hazard calculated using Cox's proportional hazard model differed significantly (P<0.01) between the GS-TAE group and the LP-TAE group (log-rank test). These results confirmed the effectiveness of LP used in combination with Gelfoam sponge for TAE of HCC.

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Authors and Affiliations

  1. Department of Radiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Japan

    Norio Nakao, Keiji Kamino & Yukio Takayasu

  2. Department of Radiology, Nara Medical University, Nara, Japan

    Hideo Uchida, Yukihiro Nishimura & Hajime Ohishi

  3. Department of Radiology, Osaka University Medical School, Osaka, Japan

    Hironobu Nakamura

  4. Department of Radiology, The Center for Adult Diseases, Osaka, Japan

    Chikazumi Kuroda & Makoto Fujita

  5. Department of Radiology, Kinki University School of Medicine, Osaka, Japan

    Hiroyasu Yoshioka & Osamu Ishida

Authors
  1. Norio Nakao
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  2. Hideo Uchida
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  3. Keiji Kamino
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  4. Yukihiro Nishimura
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  5. Hajime Ohishi
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  6. Yukio Takayasu
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  7. Hironobu Nakamura
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  8. Chikazumi Kuroda
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  9. Makoto Fujita
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  10. Hiroyasu Yoshioka
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  11. Osamu Ishida
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Nakao, N., Uchida, H., Kamino, K. et al. Effectiveness of Lipiodol in transcatheter arterial embolization of hepatocellular carcinoma. Cancer Chemother. Pharmacol. 31 (Suppl 1), S72–S76 (1992). https://doi.org/10.1007/BF00687110

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  • DOI: https://doi.org/10.1007/BF00687110

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