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Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma — a comparison of L-TAE with Farmorubicin and L-TAE with Adriamycin (second cooperative study)

  • Session I: Treatment for Operable Patients Surgery and Combined Modalities
  • Lipiodol-Transcatheterarteria Embolization, Adriamycin Farmorubicin, Analyzed Endpoints
  • Published:
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Summary

A randomized clinical trial comparing L-TAE with Farmorubicin (FARM) and L-TAE with Adriamycin (ADR) in the treatment of hepatocellular carcinoma was conducted from October 1989 through December 1990. In all, 192 hospitals participated in this study and 117 patients were entered. The patients were randomly allocated to group A (L-TAE+FARM) or group B (L-TAE+ADR). There was no significant intergroup difference in background factors. Additional treatment consisting of repeated TAE or surgery was given to 66 patients. Four factors were analyzed in this study: the percentage of reduction in tumor size, the change in the AFP level, lipiodol accumulation, and survival. None of these factors differed significantly between the two groups. The final evaluation of this study will be based on differences in survival after a long-term follow-up. Toxic effects manifested less frequently in group A than in group B, and the decrease in the platelet count in the peripheral blood was significantly lower in group A than in group B. These results suggest that FARM exerts a more favorable effect than does ADR in the treatment of hepatocellular carcinoma.

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References

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Authors and Affiliations

  1. Osaka Teishin Hospital, Karasugatsuji, Tennoji-ku, 543, Osaka, Japan

    Jun Okamura (Director)

  2. Department of Surgery, National Medical Center Hospital, Tokyo, Japan

    Saburo Kawai & Masayoshi Tani

  3. Aichi Cancer Center, Aichi, Japan

    Makoto Ogawa (Director)

  4. Department of Epidemiology and Biostatistics, School of Health Sciences, University of Tokyo, Tokyo, Japan

    Yasuo Ohashi

  5. National Oji Hospital, Oji, Japan

    Jushiro Inoue (Director Emeritus)

  6. The 1st Department of Surgery, Mie University, Mie, Japan

    Yoshifumi Kawarada

  7. The 2nd Department of Surgery, Asahikawa Medical College, Asahikawa, Japan

    Mitsuo Kusano

  8. Department of Internal Medicine, Omuta City Hospital, Omuta, Japan

    Yasuhiko Kubo

  9. Department of Radiology, The Center for Adult Diseases, Osaka

    Chikazumi Kuroda

  10. Department of Adult Diseases, Aomori Prefectural Central Hospital, Aomori, Japan

    Yu Sakata

  11. Department of Surgery, National Cancer Center Higashi Hospital, Higashi, Japan

    Yoshiyuki Shimamura

  12. Department of Internal Medicine, National Shikoku Cancer Center, Shikoku, Japan

    Kenji Jinno

  13. Department of Internal Medicine, National Konodai Hospital, Konodai, Japan

    Akira Takahashi

  14. Department of Radiology, National Cancer Center Hospital, Tokyo, Japan

    Kenichi Takayasu

  15. Department of Internal Medicine, Miyazaki Prefectural Hospital, Miyazaki, Japan

    Kazuo Tamura

  16. The 2nd Department of Surgery, Shimane Medical School, Shimane, Japan

    Naofumi Nagasue

  17. Department of Surgery, Sapporo City Hospital, Sapporo, Japan

    Yoshimi Nakanishi

  18. Department of Radiology, National Minami-Kyushu Chuo Hospital, Minami, Japan

    Masaoki Makino

  19. Department of Gastroenterology, Osaka National Hospital, Osaka, Japan

    Manabu Masuzawa

  20. Department of Radiotherapy, National Medical Center Hospital, Tokyo, Japan

    Shuichi Mikuriya

  21. Department of Surgery II, Osaka University, Osaka, Japan

    Morito Monden & Takesada Mori

  22. Radioisotope Center, Okayama University, Okayama, Japan

    Yasuhiro Yumoto

  23. Japanese Red Cross Medical Center, Japan

    Toshitsugu Oda (Director)

Authors
  1. Jun Okamura
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  2. Saburo Kawai
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  3. Makoto Ogawa
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  4. Yasuo Ohashi
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  5. Masayoshi Tani
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  6. Jushiro Inoue
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  7. Yoshifumi Kawarada
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  8. Mitsuo Kusano
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  9. Yasuhiko Kubo
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  10. Chikazumi Kuroda
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  11. Yu Sakata
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  12. Yoshiyuki Shimamura
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  13. Kenji Jinno
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  14. Akira Takahashi
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  15. Kenichi Takayasu
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  16. Kazuo Tamura
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  17. Naofumi Nagasue
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  18. Yoshimi Nakanishi
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  19. Masaoki Makino
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  20. Manabu Masuzawa
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  21. Shuichi Mikuriya
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  22. Morito Monden
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  23. Yasuhiro Yumoto
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  24. Takesada Mori
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  25. Toshitsugu Oda
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The Cooperative Study Group for Liver Cancer Treatment of Japan

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Okamura, J., Kawai, S., Ogawa, M. et al. Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma — a comparison of L-TAE with Farmorubicin and L-TAE with Adriamycin (second cooperative study). Cancer Chemother. Pharmacol. 31 (Suppl 1), S20–S24 (1992). https://doi.org/10.1007/BF00687099

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  • DOI: https://doi.org/10.1007/BF00687099

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