Abstract
To determine whether the morphometric indices of hepatocellular carcinoma (HCC) correlated with the prognoses, the microscopic morphometric values for 84 HCC cases treated by hepatic resection were studied using an image analyzer in relation.to the survival rate and the gross classification. The mean survival time (MST) was 58 months in cases with a nucleocytoplasmic area ratio (N/C) of less than 0.28; this was significantly longer than the 38-month MST in cases with an N/C of more than 0.28 (P<0.05). In stage III disease, the MST for cases with an N/C of less than 0.28 was 63 months, which was significantly longer than the MST of 13 months for cases with an N/C of more than 0.28. After relatively noncurative hepatic resection, the MST for cases with an N/C of less than 0.28 was 49 months, and this was significantly longer than the MST of 8 months for cases with an N/C of more than 0.28. The MST was 71 months for cases with a coefficient of variance of the nuclear form factor (NCV) of less than 5.5%, which was significantly longer than the MST of 33 months for cases with an NCV of more than 5.5% (P<0.05). In stage III disease, the MST was 69 months for cases with an NCV of less than 5.5%, and this was significantly longer than the MST of 29 months for cases with an NVC of more than 5.5% (P<0.05). In cases with an N/C of less than 0.28, 18% had vascular invasion and 38% had intrahepatic metastases, whereas in those with an N/C of more than 0.28, 62% had vascular invasion and 67% had intrahepatic metastases (P<0.01,P<0.05). Based on the results of these morphometric studies on HCC cases treated by hepatic resection, N/C and NCV may be useful as prognostic factors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Arii S, Tanaka J, Yamazoe Y, Minematsu S, Morino T, Fujita K, Maetani S, Tobe T (1992) Predictive factors for intrahepatic recurrence of hepatocellular carcinoma after partial hepatectomy. Cancer 69: 913
Edmondson HA, Steiner PE (1954) Primary carcinoma of the liver. A study of 100 cases among 48,900 necropsies. Cancer 7: 462
Ito Y, Tarao K, Kuni Y, Shimizu A, Harada M, Tamai S, Fujimoto Y, Sugimasa I, Takemiya S, Okamoto A (1989) The relation between DNA synthesis estimated by BrdU uptake and Edmondson and Steiner's classification in hepatocellular carcinoma (in Japanese) Acta Hepatol Jpn 30: 538
Jwo SC, Chiu JH, Chau GY, Loong CC, Lui WY (1992) Risk factors linked to tumor recurrence of human hepatocellular carcinoma after hepatic resection. Hepatology 16: 1367
Kawai Y, Yamamoto S, Takeshige K, Arakawa T, Kuroda H, Kito M, Suzuki H, Hasegawa M, Tanaka N, Tanaka K, Koide T, Ishikawa S (1988) An evaluation of treatments from their prognosis in patients with hepatocellular carcinoma (in Japanese). Jpn J Gastroenterol Surg 21: 1248
Kawarada Y, Imai T, Iwata M, Yokoi H, Noguchi T, Mizumoto R (1992) Significance of multidisciplinary therapy for hepatocellular carcinoma. Cancer Chemother Pharmacol 31 [Suppl 1]: S13
Kondo F, Wada K, Nagato Y, Nakajima T, Kondo Y, Hirooka N, Ebara M, Ohto M, Okuda K (1989) Biopsy diagnosis of well-differentiated hepatocellular carcinoma based on new morphologic criteria. Hepatology 9: 751
Liver Cancer Study Group of Japan (1992) The general rules for the clinical and pathological study of primary liver cancer. Kanehara & Co., Ltd., Tokyo, p 34
Motohashi I, Okudaira M, Takai T, Kaneko S, Futagami R (1990) Micro-morphometric investigations of hepatocellular carcinomas (HCC) and HCC-like liver lesions with particular emphasis on nuclear and cellular pleomorphism (in Japanese). Acta Hepatol Jpn 31: 1274
Nonami T, Isshiki K, Katoh H, Kishimoto W, Harada A, Nakao A, Takagi H (1991) The potential role of postoperative hepatic artery chemotherapy in patients with high-risk hepatomas. Ann Surg 213: 222
Takeshige K, Kawai Y, Kuroda H, Suzuki H, Hasegawa M, Kamiya H, Tanaka N, Tanaka K, Banno K, Ishikawa S, Kobayashi H, Yamamoto S (1990) Hepatocellular carcinoma: relation between gross classification, staging and late results (in Japanese). Tumor Infect 3: 709
Tanaka K, Nakamura S, Numata K, Okazaki H, Endo O, Inoue S, Takamura Y, Sugiyama M, Ohaki Y (1992) Hepatocellular carcinoma: treatment with percutaneous ethanol injection and transcatheter arterial embolization. Radiology 185: 457
Tarao K, Shimizu A, Harada M, Ohkawa S, Tamai S, Ito Y, Kuni Y, Takemiya S, Okamoto T (1990) Increased DNA synthetic potency of hepatocytes in cirrhotic patients may indicate a super-high risk for hepatocellular carcinoma. Jpn J Med 29: 373
Utsunomiya T, Matsumata T, Adachi E, Honda H, Sugimachi K (1992) Limitations of current preoperative liver imaging techniques for intrahepatic metastatic nodules of hepatocellular carcinoma. Hepatology 16: 694
Yoshimi F, Nagao T, Inoue S, Kawano N, Muto T, Gunji T, Ohnishi S, Imawari M (1992) Comparison of hepatectomy and transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma: necessity for prospective randomized trial. Hepatology 16: 702
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kawai, Y., Takeshige, K., Nunome, M. et al. Prognosis after hepatic resection in patients with hepatocellular carcinoma, estimated on the basis of the morphometric indices. Cancer Chemother. Pharmacol. 33 (Suppl 1), S24–S28 (1994). https://doi.org/10.1007/BF00686663
Issue Date:
DOI: https://doi.org/10.1007/BF00686663