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Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines

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  • Polyamine Analog Cell Cycle, Glion
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Abstract

1,14-Bis-(ethyl)-amino-5,10-diazatetradecaneN 1,N 11-bis(ethyl)norspermine (BE-4-4-4) and 1,19-bis-(ethylamino)-5,10,15 triazanonadecane (BE-4-4-4-4) are two relatively new polyamine analogs synthesized for use as antineoplastic agents. In human brain tumor cell lines U-251 MG and SF-767, both agents inhibited cell growth, were cytotoxic, induced a variable G1/S block, and depleted intracellular polyamines. Since intracellular polyamine depletion did not always correlate with growth inhibition, cell survival, or cell cycle progression, it cannot completely explain the effects of these agents on growth, survival, and cell cycle progression in U-251 MG and SF-767 cells.

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Author notes

  1. Burt G. Feuerstein

    Present address: Department of Neurological Surgery, c/o The Editorial Office, 1360 Ninth Avenue, Suite 210, 94122, San Francisco, CA, USA

Authors and Affiliations

  1. Bram Tumor Research Center, Department of Neurological Surgery, School of Medicine, University of California, 94143, San Francisco, CA, USA

    Christophe J. Bergeron, Hirak S. Basu, Laurence J. Marton, Dennis F. Deen, Malgorzata Pellarin & Burt G. Feuerstein

  2. Division of Molecular Cytometry, Department of Laboratory Medicine, School of Medicine, University of California, 94143, San Francisco, CA, USA

    Burt G. Feuerstein

  3. Department of Radiation Oncology, School of Medicine, University of California, 94143, San Francisco, CA, USA

    Dennis F. Deen

  4. Departments of Pathology/Laboratory Medicine, Oncology, and Human Oncology, School of Medicine, University of Wisconsin, 53706-1532, Madison, WI, USA

    Laurence J. Marton

Authors
  1. Christophe J. Bergeron
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  2. Hirak S. Basu
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  4. Dennis F. Deen
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  5. Malgorzata Pellarin
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  6. Burt G. Feuerstein
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Additional information

This work was supported by grants CA 13525 and CA 49409 from the National Cancer Institute, by the Association pour la Recherche sur le Cancer (Villejuif), and by the National Brain Tumor Foundation

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Bergeron, C.J., Basu, H.S., Marton, L.J. et al. Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines. Cancer Chemother. Pharmacol. 36, 411–417 (1995). https://doi.org/10.1007/BF00686190

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  • DOI: https://doi.org/10.1007/BF00686190

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