Skip to main content

Advertisement

SpringerLink
Log in

Phase II study of single-agent etoposide in patients with metastatic squamous-cell carcinoma of the esophagus

  • Original Articles
  • Single-Agent Etoposide, Metastatic Squamous-Cell Carcinoma, Esophagus
  • Published:
Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Summary

A total of 26 evaluable patients presenting with advanced or metastatic squamous-cell carcinoma of the esophagus were entered in a phase II trial to assess the single-agent activity of etoposide. Etoposide was given at a dose of 200 mg/m2 on 3 consecutive days every 3 weeks. Five patients (19%) achieved a partial response and seven (27%) experienced stabilisation of their disease. The median duration of response was 4 months (range 3–8 months). The major toxicity was leukopenia, which reached WHO grade 3 in 46% of patients and grade 4 in 11% of cases, with five instances of leukopenic fever and one therapy-associated death being recorded. Etoposide given at this dose and on this schedule seems to have considerable activity against non-pretreated metastatic esophageal carcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Coonley C, Bains M, Heelan R, Dukeman M, Kelsen DP (1983) Phase II study of etoposide in the treatment of esophageal carcinoma. Cancer Treat Rep 67:397

    Google Scholar 

  2. Engström P, Lavin PT, Klaasen OJ (1983) Phase II evaluation of mitomycin and cisplatin in advanced esophageal carcinoma. Cancer Treat Rep 67:713

    Google Scholar 

  3. Ezdinli EZ, Gelber R, Desai DV, Falkson G, Moertel CG, Hahn RG (1980) Chemotherapy of advanced esophageal carcinoma: Eastern Cooperative Oncology Group experience. Cancer 46:2149

    Google Scholar 

  4. Kelsen DP (1984) Chemotherapy of esophageal cancer. Semin Oncol 11:159

    Google Scholar 

  5. Kelsen DP, Bains MS, Cvitkovic E (1979) Vindesine in the treatment of esophageal carcinoma: a phase II study. Cancer Treat Rep 63:2019

    Google Scholar 

  6. Panettiere F, Leichman L, Tilchen E (1984) Chemotherapy for advanced epidermoid carcinoma of the esophagus with single agent cisplatin: final report of a Southwest Oncology Group study. Cancer Treat Rep 68:1023

    Google Scholar 

  7. Radice R, Bunn P, Ihde D (1979) Therapeutic trials with VP-16 and VM-26. Cancer Treat Rep 63:1231

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology and Oncology, University of Hannover Medical School, K.-Gutschow-Strasse 8, W-3000, Hannover 61, FRG

    Andreas Harstrick, Carsten Bokemeyer, Claus Henning Köhne-Wömpner, Hans-Joachim Meyer, Heike Knipp & Hans-Joachim Schmoll

  2. Department of Abdominal Surgery, University of Hannover, Hannover, FRG

    Andreas Harstrick, Carsten Bokemeyer, Claus Henning Köhne-Wömpner, Hans-Joachim Meyer, Heike Knipp & Hans-Joachim Schmoll

  3. Department of Oncology, West German Cancer Center, Essen, FRG

    Michael Stahl & Hansjochen Wilke

  4. Department of Surgery, University of Muenster, Muenster, FRG

    Peter Preusser

Authors
  1. Andreas Harstrick
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carsten Bokemeyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter Preusser
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Claus Henning Köhne-Wömpner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hans-Joachim Meyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Michael Stahl
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Heike Knipp
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hans-Joachim Schmoll
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hansjochen Wilke
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harstrick, A., Bokemeyer, C., Preusser, P. et al. Phase II study of single-agent etoposide in patients with metastatic squamous-cell carcinoma of the esophagus. Cancer Chemother. Pharmacol. 29, 321–322 (1992). https://doi.org/10.1007/BF00685952

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00685952

Keywords

Search

Navigation