Summary
For 56 cases of carcinoma of the breast, results of the immunocytochemical assay for estrogen and progesterone receptors performed on preoperative fine-needle aspirates were compared with those obtained on scraping material from the same tumors. The value and usefulness of this last analysis was demonstrated in a previous study.
The level of agreement between the two cytological techniques was assessed by the k statistic. A high level of agreement was found, with k values of 0.909 and 0.889 for estrogen and progesterone receptors, respectively.
The results reported here revealed the reliability of steroid receptor determination on fine-needle aspiration biopsies, provided that sufficient cellularity was available. This technique can replace the open biopsy procedure, inasmuch as it represents a rapid, almost painless, and easily repeated method for the assessment of the receptor status, and is useful for treatment decisions at any time during the course of the disease.
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Frigo, B., Pilotti, S., Zurrida, S. et al. Analysis of estrogen and progesterone receptors on preoperative fine-needle aspirates. Breast Cancer Res Tr 33, 179–184 (1995). https://doi.org/10.1007/BF00682725
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DOI: https://doi.org/10.1007/BF00682725