Abstract
The purpose of the present study was to establish the extent of the amblyopic deficit at 0°, 10°, and 20° retinal eccentricity using contrast sensitivity measures for sine wave gratings subtending various field sizes. Contrast sensitivity functions were shown to vary with stimulus field size, retinal location and degree of amblyopia. Foveally, peak contrast sensitivity of amblyopic eyes increased markedly with increasing field size, to reach the same magnitude as that of the contralateral non-amblyopic eyes for large fields. Peripherally, peak contrast sensitivity remained lower in the amblyopic eyes for all field sizes examined. High spatial frequency cut-offs were reduced both centrally and peripherally with all field sizes in the amblyopic eyes. The effect of increasing field size on the cut-off acuity was found to be smaller than the effect on-peak contrast sensitivity.
The most significant conclusions drawn from the results are that: (1) The amblyopic deficit in terms of both peak contrast sensitivity and acuity isnot restricted to the central foveal region; and (2) amblyopic eyes benefit to a greater extent from increased stimulus field size than non-amblyopic eyes in terms of peak contrast sensitivity.
A model is proposed which suggests that the results obtained are due to fewer and/or less sensitive cortical neurons being driven by the amblyopic eye in humans with naturally occurring amblyopia.
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References
Aulhorn E and Lichtenberg C (1972) Central and peripheral visual acuity of eyes suffering from strabismus amblyopia. In Orthoptics Proceedings of the Second International Orthoptics Congress. Ed. J Mein, JJM Bierlaagh and Tea BrumnelKanp-Dons Exerpta Medica Amsterdam: p. 153–160
Avetisov ES (1978) Visual acuity and contrast sensitivity of the amblyopic eye as a function of the stimulated region of the retina. (Translation). Amer J Optom Phys Opt 56:465–469
Bedell HE (1982) Symmetry of acuity profiles in esotropic amblyopic eyes. Human Neurobiol 1:221–224
Bedell HE (1978) Retinal receptor orientation in amblyopic and non-amblyopic eyes assessed at several retinal locations using the psychophysical Stiles-Crawford function. PhD Dissertation, University of Florida
Bedell HE and Flom MC (1981) Monocular spatial distortion in strabismic amblyopia. Invest Ophthal Vis Sci 20:263–268
Burian HM (1967) The behavior of the amblyopic eye under reduced illumination and the theory of functional amblyopia. Docum Ophthal 23:189–202
Campbell FW and Green DG (1965) Optical and retinal factors affecting visual resolution. J Physiol (London) 181:576–593
Chavasse BF (1939)Worth's Squint, 7th Ed. Philadelphia, Blakiston
Cowey A and Rolls ET (1974) Human cortical magnification factor and its relation to visual acuity. Exp Brain Res 21:447–454
De Valois R, Albrecht DG and Thorell LG (1982) Spatial frequency selectivity of cells in macaque visual cortex. Vision Res 22:545–559
Eggers HM and Blakemore C (1978) Physiological basis of anisometropic amblyopia. Science 201:264–267
Flynn JT (1967) Spatial summation in amblyopia. Arch Ophthal 78:470–474
Grosvenor T (1957) The effect of duration and background luminance upon the brightness discrimination of the amblyope. Amer J Optom 31:639–663
Gstalder RJ and Gree DG (1971) Laser interferometric acuity in amblyopia. J Ophthal 8:251–256
Hagemans KH and van der Wildt GJ (1979) The influence of the stimulus width on the contrast sensitivity function in amblyopia. Invest Ophthal Vis Sci 18:842–847
Harwerth RS (1982) Behavioral studies of amblyopia in monkeys. Amer J Optom Phys Opt 59:535–555
Hess RF (1977) Assessment of stimulus field size for strabismic amblyopes. Amer J Optom Phys Opt 54:292–299
Hess RF and Howell ER (1977) The threshold contrast sensitivity function in strabismic amblyopia: Evidence for a two type classification. Vision Res 17:1049–1056
Hess RF and Howell ER (1978) The influence of field size for a periodic stimulus in strabismic amblyopia. Vision Res 18:501–503
Hess RF and Woo G (1978) Vision through cataracts. Invest Ophthal Vis Sci 17: 428–435
Hess RF and Jacobs RJ (1979) A preliminary report of acuity and contour interaction across the amblyope's visual field. Vision Res 19:1403–1408
Hess RF (1980) A preliminary investigation of neural function and dysfunction in amblyopia, I–III. Vision Res 20:749–760
Hess RF, Campbell FW and Zimmern R (1980) Differences in the neural basis of human amblyopias: The effect of mean luminance. Vision Res 20:295–305
Hess R and Bradley A (1980) Contrast perception above threshold is only minimally impaired in human amblyopia. Nature 287:463–464
Hubel DH and Wiesel TN (1968) Receptive fields and functional architecture of monkey striate cortex. J Physiol (London) 195:215–243
Hubel DH Wiesel TN and LeVay S (1975) Functional architecture of area 17 in normal and monocularly deprived macaque monkeys.Cold Spring Harbor Symposium on Quantitative Biology 40:581–589
Ikeda H and Wright MJ (1975) A possible neurophysiological basis for amblyopia. Br Orthopt J 32:2–13
Katz LM (1982) Contrast sensitivity of the amblyopic eye in central and peripheral retina with variation of stimulus field size - Implications for its neural basis.Thesis, University of Houston
Kirschen DA and Flom MC (1978) Visual acuity at different retinal loci of eccentrically fixating functional amblyopes. Amer J Optom Physiol Opt 55:144–150
Koenderink JJ, Bouman MA, Bueno de Mesquita AE and Siappendel S (1978) Perimetry of contrast detection thresholds of moving spatial sine wave patterns, I–IV. J Opt Soc Amer 68:845–865
Lawden MC, Hess RF and Campbell FW (1982) The discriminability of spatial phase relationships in amblyopia. Vision Res 22; 1005–1016
Lawill T, Meur G and Howard CW (1973) Lateral inhibition in the central visual field of an amblyopic subject. Am J Ophthal 76:225–228
Levi DM and Harwerth RS (1977) Spatio-temporal interactions in anisometropic and strabismic amblyopia. Invest Ophthal Vis Sci 16:90–95
Levi DM, Harwerth RS, Pass AF and Venverloh J (1981) Edge sensitive mechanisms in humans with abnormal visual experience. Exp Brain Res 43:270–280
Levi DM and Klein S (1982) Differences in vernier discrimination for gratings between strabismic and anisometropic amblyopes. Invest Ophthal Vis Sci 23: 398–407
Levi DM, Klein SA and Aitsebaomo (1984) Detection and discrimination of the direction of motion in central and peripheral vision of normal and amblyopic observers. Vision Res 24:789–800
Loshin DS and Levi DM (1983) Suprathreshold contrast perception in functional amblyopia. Docum Ophthal 55:213–232
Miller EF (1955) Investigation of the nature and cause of impaired acuity in amblyopia. Amer J Optom 32: 10–29
Pass AF and Levi DM (1982) Spatial processing of complex stimuli in the amblyopic. Invest Ophthal Vis Sci 23:780–786
Rovamo J and Virsu V (1979) An estimation and application of the human cortical magnification factor. Exp Brain Res 37: 495–510
Rovamo J, Virsu V and Nasanen R (1978) Cortical magnification factor predicts the photopic contrast sensitivity of peripheral visioa Nature (London) 217:54–56
Schor CM and Hallmark W (1978) Slow control of eye position in amblyopia. Invest Ophthal Vis Sci 17:577–581
Sireteanu R and Fronius M (1981) Naso-temporal asymmetries in human amblyopia: Consequence of long term interocular suppression. Vision Res 21:1055–1063
Thomas J (1978) Normal and amblyopic contrast sensitivity functions in central and peripheral retinae. Invest Ophthal 17:746–753
Tremain KE and Ikeda H (1982) Relationship between amblyopia, LGN cell ‘shrinkage’ and cortical ocular dominance in cats. Exp Brain Res 45:243–252
Virsu V and Rovamo J (1979) Visual resolution, contrast sensitivity and the cortical magnification factor. Exp Brain Res 37:475–494
Von Noorden GK (1977). Mechanisms of amblyopia. Adv Ophthal 34:93–115
Wetherill AB and Levitt H (1965) Sequential estimation of points on a psychometric function. Brit J Math Stat Psych 18:1
Weymouth FW (1958) Visual sensory units and the minimum angle of resolution. Amer J Ophthal 46:102–113
Worth CA and Chavasse FB (1950) Squint, its causes, pathology and treatment, 8th ed., ed. by T.K. Lyle. Philadelphia, Blackston
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Supported in part by NEI grant R01EY01728 from the National Eye Institute, NIH, Bethesda, Maryland
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Katz, L.M., Levi, D.M. & Bedell, H.E. Central and peripheral contrast sensitivity in amblyopia with varying field size. Doc Ophthalmol 58, 351–373 (1984). https://doi.org/10.1007/BF00679799
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DOI: https://doi.org/10.1007/BF00679799