Summary
The effect of ketanserin on macrocirculatory and microcirculatory blood flow was investigated in a placebo-controlled, double-blind trial in 11 patients suffering from intermittent claudication using Doppler velocimetry and intravital skin capillary microscopy, respectively.
After 1 year of treatment no significant change was observed either in the ketanserin or the placebo group. It appears that ketanserin has no significant effect on macrocirculatory blood flow and microcirculatory nutritional skin blood flow in patients with intermittent claudication.
This is a preview of subscription content, log in via an institution to check access.
References
De Cree J, Leempoels J, Geukens H, Verhaegen H (1984) Placebo-controlled double-blind trial of ketanserin in treatment of intermittent claudication. Lancet 2: 775–779
Bounameaux H, Holditch T, Hellemans H, Berent A, Verhaeghe R (1985) Placebo-controlled, double-blind, two-centre trial of ketanserin in intermittent claudication. Lancet 2: 1268–1271
Cameron HA, Waller PC, Ramsay LE (1987) Placebo-controlled trial of ketanserin in the treatment of intermittent claudication. Angiology 38: 549–555
Jacobs MJHM, Slaaf DW, Lemmens HAJ, Reneman RS (1987) The use of hemorheological and microcirculatory parameters in evaluating the effect of treatment in Raynaud's phenomenon. Vasc Surg 21: 9–16
Bollinger A, Butti P, Barras JP, Trachsler H, Siegenthaler W (1974) Red blood cell velocity in nailfold capillaries of man measured by a television microscopy technique. Microvasc Res 7: 61–72
Verstraete M (Prevention of Atherosclerotic Complications with Ketanserin Trial Group) (1989) Prevention of atherosclerotic complications: controlled trial of ketanserin. Br Med J 298: 424–430
Boss Ch, Schneuwly P, Mahler F (1987) Evaluation and clinical application of the flying spot method in clinical nailfold capillary TV-microscopy. Int J Microcirc Clin Exp 6: 15–23
Dormandy JA, Hoare E, Colley J, Arrowsmith DE, Dormandy TL (1973) Clinical, haemodynamic, rheological and biochemical findings in 126 patients with intermittent claudication. Br Med J 4: 576–581
Walker RT, Matrai A, Bogar L, Dormandy JA (1985) Serotonin and the flow properties of blood. J Cardiovasc Pharmacol 7 [Suppl 7]: S35-S37
Wenting GJ, Man in 't Veld AJ, Woittiez AJ, Boomsma F, Schalekamp MADH (1982) Treatment of hypertension with ketanserin, a new selective 5-HT2 receptor antagonist. Br Med J 284: 537–539
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Beckers, R.C.Y., Jörning, P.J.G., Slaaf, D.W. et al. Effect of ketanserin on macrocirculatory and microcirculatory blood flow in patients with intermittent claudication. A prospective randomized study. Eur J Clin Pharmacol 37, 295–296 (1989). https://doi.org/10.1007/BF00679787
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00679787