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Immunchemische Untersuchungen zum Problem der „pregnancy zone“ X. Nachweis immunsuppressiver Aktivitäten des schwangerschaftsassoziiertenα 2-Glykoproteins (Protein der „pregnancy zone“) mit Hilfe des Makrophagen-Elektrophorese-Mobilitätstestes

Immunochemical investigations on the protein of the “pregnancy zone“ X. Demonstration of immunosuppressive activities of the pregnancy-associated α2-glycoprotein (pregnancy zone protein) by means of the macrophage electrophoretic mobility test

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Summary

By means of the macrophage electrophoretic mobility (MEM) test the supposed immunosuppressive activity of the pregnancy-associated α2-glycoprotein (pregnancy zone protein) could be demonstrated significantly. Pregnancy sera and sera of nonpregnant women with hormonal contraception containing this pregnancy protein showed an immunosuppressive activity, too. On the contrary, serum of male donors with the blood group AB and human serum albumin had no inhibitory effects. The results suggest that the pregnancy-associated α2-glycoprotein rather influences the afferent limb of the immune response and does not interfere with the activity of the mediator (migration inhibiting factor).

Zusammenfassung

Mit Hilfe des Makrophagen-Elektrophorese-Mobilitätstestes konnte die vermutete immunsuppressive Aktivität des schwangerschaftsassoziiertenα 2-Glykoproteins (Protein der „pregnancy zone“) signifikant nachgewiesen werden. Seren von Schwangeren sowie Nichtschwangeren unter hormonaler Kontrazeption die dieses Schwangerschaftsprotein enthielten, wiesen ebenfalls eine immunsuppressive Aktivität auf. Dagegen waren männliches AB-Spenderserum und menschliches Serumalbumin nicht immunsuppressiv wirksam. Aus den Versuchen läßt sich ableiten daß das schwangerschaftsassoziierte α2-Glykoprotein eher auf den afferenten Schenkel der Immunantwort einwirkt und nicht mit der Wirkung des Mediators (migration inhibiting factor) interferiert.

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Authors and Affiliations

  1. Frauenklinik und Forschungsabteilung Immunologie, des Bereiches Medizin der Universität Rostock, Deutsche Demokratische Republik

    W. Straube, B. Klausch, R. Hofmann, H. -L. Jenssen, J. Günther & H. Köhler

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  1. W. Straube
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  2. B. Klausch
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  3. R. Hofmann
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  4. H. -L. Jenssen
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  5. J. Günther
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  6. H. Köhler
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Straube, W., Klausch, B., Hofmann, R. et al. Immunchemische Untersuchungen zum Problem der „pregnancy zone“ X. Nachweis immunsuppressiver Aktivitäten des schwangerschaftsassoziiertenα 2-Glykoproteins (Protein der „pregnancy zone“) mit Hilfe des Makrophagen-Elektrophorese-Mobilitätstestes. Arch. Gynak. 218, 313–322 (1975). https://doi.org/10.1007/BF00672332

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