References
Auerbach R: Patterns of tumor metastasis: organ selectivity in the spread of cancer cells. Lab Invest 58: 361–364, 1988
Nicolson GL: Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites. Biochim Biophys Acta 948: 175–224, 1988
Blood CH, Zetter BR: Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim Biophys Acta 1032: 89–118, 1990
McCormick BA, Zetter BR: Adhesive interactions in angiogenesis and metastasis. Pharmac Ther 53: 239–260, 1992
Liotta LA: Tumor invasion and metastases - role of the extracellular matrix: Rhoads memorial award lecture. Cancer Res 46: 1–7, 1986
Liotta LA, Steeg PS, Stetler-Stevenson WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64: 327–336, 1991
Kaminski M, Auerbach R: Tumor cells are protected from NK-cell-mediated lysis by adhesion to endothelial cells. Int J Cancer 41: 847–849, 1988
Behrens J: The role of cell adhesion molecules in cancer invasion and metastasis. Breast Cancer Res Treat 24: 175–184, 1993
Coman DR: Mechanism of the invasiveness of cancer. Science 105: 347–348, 1947
Weinstein RS, Merk FB, Alroy J: The structure and function of intercellular junctions in cancer. Adv Cancer Res 23: 23–89, 1976
Bastida E: The metastatic cascade: potential approaches for the inhibition of metastasis. Semin Thromb Hemost 14: 66–72, 1988
De Bruyn PPH, Cho Y: Vascular endothelial invasion via transcellular passage by malignant cells in the primary stage of metastases formation. J Ultrastruct Res 81: 189–201, 1982
Takeichi M: Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251: 1451–1455, 1991
Yoshida CN, Suzuki N, Takeichi M: Molecular nature of the calcium-dependent cell-cell adhesion system in mouse teratocarcinoma and embryonic cell studied with a monoclonal antibody. Dev Biol 101: 19–27, 1984
Nose A, Takeichi M: A novel cadherin cell adhesion molecule: its expression petterns associated with implantation and organogenesis of mouse embryos. J Cell Biol 103: 2649–2658, 1986
Hatta K, Okada TS, Takeichi M: A monoclonal antibody disrupting calcium-dependent cell-cell adhesion of brain tissues: possible role of its target antigen in animal pattern formation. Proc Natl Acad Sci USA 82: 2789–2793, 1985
Gallin WJ, Edelman GM, Cunningham BA: Characterization of L-CAM, a major cell adhesion molecule from embryonic liver cells. Proc Natl Acad Sci USA 80: 1038–1042, 1983
Behrens J, Mareel MM, Roy FMV, Birchmeier W: Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 108: 2435–2447, 1989
Vleminckx K, Vakaet Jr L, Mareel M, Fiers W, Roy FV: Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66: 107–119, 1991
Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Löchner D, Birchmeier W: E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113: 173–185, 1991
Sommers CL, Thompson EW, Torri JA, Kemler R, Gelmann EP, Byers SW: Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities. Cell Growth Diff 2: 365–372, 1991
Doki Y, Schiozaki H, Tahara H, Inoue M, Oka H, Iihara K, Kadowaki T, Takeichi M, Mori T: Correlation between Ecadherin expression and invasivenessin vitro in a human esophageal cancer cell line. Cancer Res 53: 3421–3426, 1993
Shiozaki H, Tahara H, Oka H, Miyata M, Kobayashi K, Tamura S, Iihara K, Doki Y, Hirano S, Takeichi M, Mori T: Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol 139: 17–23, 1991
Mayer B, Johnson JP, Leitl F, Jauch KW, Heiss MM, Schildberg FW, Birchmeier W, Funke I: E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res 53: 1690–1695, 1993
Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H, Kobayashi T, Takatsuka Y, Matsuyoshi N, Hirano S, Takeichi M, Mori T: Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 53: 1696–1701, 1993
Hashimoto M, Niwa O, Nitta Y, Takeichi M, Yokoro K: Unstable expression of E-cadherin adhesion molecules in metastatic ovarian tumor cells. Jpn J Cancer Res 80: 459–463, 1989
Umbas R, Schalken JA, Aalders TW, Carter BS, Karthaus HFM, Schaafsma HE, Debruyne FMJ, Isaacs WB: Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res 52: 5104–5109, 1992
Tohma Y, Yamashita Y, Yamashita J: Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas. Cancer Res 52: 1981–1987, 1992
Shimoyama Y, Hirohashi S: Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma. Cancer Lett 57: 131–135, 1991
Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K, Birchmeier W: E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 51: 6328–6337, 1991
Morton RA, Ewing CM, Nagafuchi A, Tsukita S, Isaacs WB: Reduction of E-cadherin levels and deletion of the α-catenin gene in human prostate cancer cells. Cancer Res 53: 3585–3590, 1993
Rutishauser U, Hoffman S, Edelman GM: Binding properties of a cell adhesion molecule from neural tissue. Proc Natl Acad Sci USA 79: 685–689, 1982
Cunningham BA, Hemperly JJ, Murray BA, Prediger EA, Brackenbury R, Edelman GM: Neural cell adhesion molecule: Structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. Science 236: 799–806, 1987
Andersson AM, Moran N, Linneman D, Bjerkvig R, Laerum OD, Bock E: Characterization of NCAM expression and function in BT4C and BT4Cn glioma cells. Int J Cancer 47: 124–129, 1991
Linnemann D, Raz A, Bock E: Differential expression of cell adhesion molecules in variants of K1735 melanoma cells differing in metastatic capacity. Int J Cancer 43: 709–712, 1989
Faeron ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW, Vogelstein B: Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247: 49–56, 1990
Narayanan R, Lawlor KG, Schaapveld RQJ, Cho KR, Vogelstein B, Tran PB-V, Osborne MP, Telang NT: Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts. Oncogene 7: 553–561, 1992
Yanoshita RK, Konishi M, Fukunari H, Tanaka K, Miyaki M: Loss of expression of the DCC gene during progression of colorectal carcinomas in familial adenomatous polyposis and non-familial adenomatous polyposis patients. Cancer Res 52: 3801–3803, 1992
Höhne MW, Halatsch M-E, Kahl GF, Weinel RJ: Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. Cancer Res 52: 2616–2619, 1992
Devilee P, van Vliet M, Kuipers-Dijkshoorn N, Pearson PL, Cornelisse CJ: Somatic genetic changes on chromosome 18 in breast carcinomas: is the DCC gene involved? Oncogene 6: 311–315, 1991
Adamson IYR, Young L, Orr FW: Tumor metastasis after hyperoxic injury and repair of the pulmonary endothelium. Lab Invest 57: 71–77, 1987
Morris VL, MacDonald IC, Koop S, Schmidt EE, Chambers AF, Groom AC: Early interactions of cancer cells with the microvasculature in mouse liver and muscle during hematogenous metastasis: videomicroscopic analysis. Clin Exp Metastasis 11: (in press), 1993
Rusciano D, Burger MM: Why do cancer cells metastasize into particular organs? BioEssays 14: 185–194, 1992
Auerbach R, Lu WC, Pardon E, Gumkowski F, Kaminska G, Kaminska M: Specificity of adhesion between murine tumor cells and capillary endothelium: anin vitro correlate of preferential metastasisin vivo. Cancer Res 47: 1492–1496, 1987
Johnson RC, Augustin-Voss HG, Zhu D, Pauli BU: Endothelial cell membrane vesicles in the study of organ preference of metastasis. Cancer Res 51: 394–399, 1991
McCarthy SA, Kuzu I, Gatter KC, Bicknell R: Heterogeneity of the endothelial cell and its role in organ preference of tumour metastasis. TiPS 12: 462–467, 1991
Cummings RD, Smith DF: The selectin family of carbohydrate-binding proteins: structure and importance of carbohydrate ligands for cell adhesion. BioEssay 14: 849–856, 1992
Bevilacqua MP, Stengelin S, Gimbrone Jr MA, Seed B: Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243: 1160–1165, 1989
Phillips ML, Nudelman E, Gaeta FCA, Perez M, Singhal AK, Hakomori S, Paulson JC: ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. Science 250: 1130–1132, 1990
Berg EL, Robinson MK, Mansson O, Butcher EC, Magnani JL: A carbohydrate domain common to both sialyl Lea and sialyl Lex is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. J Biol Chem 266: 14869–14872, 1991
Hoff SD, Matsushita Y, Ota DM, Cleary KR, Yamori T, Hakomori S, Irimura T: Increased expression of sialyl-dimeric Lex antigen in liver metastases of human colorectal carcinoma. Cancer Res 49: 6883–6888, 1989
Nakamori S, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, Sasaki Y, Kabuto T, Iwanaga T, Matsushita Y, Irimura T: Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res 53: 3632–3637, 1993
Fukushima K, Hirota M, Terasaki PI, Wakisaka A, Togashi H, Chia D, Suyama N, Fukushi Y, Nudelman E, Hakomori S: Characterization of sialosylated Lewisx as a new tumorassociated antigen. Cancer Res 44: 5279–5285, 1984
Sakamoto J, Watanabe T, Tokumaru T, Takagi H, Nakazato H, Lloyd KO: Expression of Lewisa, Lewisb, Lewisx, Lewisy, sialyl-Lewisa, and sialyl-Lewisx blood group antigens in human gastric carcinoma and in normal gastric tissue. Cancer Res 49: 745–752, 1989
Rice GE, Bevilacqua MP: An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science 246: 1303–1306, 1989
Matsushita Y, Nakamori S, Seftor EA, Hendrix MJC, Irimura T: Human colon carcinoma cells with increased invasive capacity obtained by selection for sialyl-dimeric Lex antigen. Exp Cell Res 196: 20–25, 1991
Osborn L, Hession C, Tizard R, Vassallo C, Luhowskyj S, Chi-Rosso G, Lobb R: Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59: 1203–1211, 1989
Elices MJ, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME, Lobb RR: VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60: 577–584, 1990
Taichman DB, Cybulsky MI, Djaffar I, Longenecker BM, Teixidó J, Rice E, Aruffo A, Bevilacqua MB: Tumor cell surface α4β1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1. Cell Regul 2: 347–355, 1991
Mattila P, Majuri M-L, Renkonen R: VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1 differential regulation of the VLA-4 avidity on various sarcoma cell lines. Int J Cancer 52: 918–923, 1992
Orr FW, Adamson IYR, Young L: Pulmonary inflammation generates chemotactic activity for tumor cells and promotes lung metastasis. Am Rev Respir Dis 131: 607–611, 1985
Murthy SM, Goldschmidt RA, Rao LN, Ammirati M, Buchmann T, Scanlon EF: The influence of surgical trauma on experimental metastasis. Cancer 64: 2035–2044, 1989
Hart IR, Birch M, Marshall JF: Cell adhesion receptor expression during melanoma progression and metastasis. Cancer Metast Rev 10: 115–128, 1991
Spriggs D, Imamura K, Rodriguez C, Horiguchi J, Kufe DW: Induction of tumor necrosis factor expression and resistance in a human breast tumor cell line. Proc Natl Acad Sci 84: 6563–6566, 1987
Goldstein LA, Zhou DFH, Picker LJ, Minty CN, Bargatze RF, Ding JF, Butcher EC: A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell 56: 1063–1072, 1989
Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B: CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303–1313, 1990
Jalkanen S, Bargatze RF, de los Toyos J, Butcher EC: Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85–95D glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells. J Cell Biol 105: 983–990, 1987
Gallatin M, St John TP, Siegelman M, Reichert R, Butcher EC, Weissman IL: Lymphocyte homing receptors. Cell 44: 673–680, 1986
Stamenkovic I, Amiot M, Pesando JM, Seed B: A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell 56: 1057–1062, 1989
Sher BT, Bargatze R, Holtzmann B, Gallatin WM, Matthews D, Wu N, Picker L, Butcher EC, Weissman IL: Homing receptors and metastasis. Adv Cancer Res 51: 361–390, 1988
Birch M, Mitchell S, Hart IR: Isolation and characterization of human melanoma cell variants expressing high and low levels of CD44. Cancer Res 51: 6660–6667, 1991
Günthert U, Hofmann M, Rudy W, Reber S, Zöller M, Haussmann I, Matzku S, Wenzel A, Ponta H, Herrlich P: A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65: 13–24, 1991
Seiter S, Arch R, Reber S, Komitowski D, Hofmann M, Ponta H, Herrlich P, Matzku S, Zöller M: Prevention of tumor metastasis formation by anti-variant CD44. J Exp Med 177: 443–455, 1993
Hofmann M, Rudy W, Zöller M, Tölg C, Ponta H, Herrlich P, Günthert U: CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. Cancer Res 51: 5292–5297, 1991
Rudy W, Hofmann M, Schwartz-Albiez R, Zöller M, Heider K-H, Ponta H, Herrlich P: The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior. Cancer Res 53: 1262–1268, 1993
Heider K-H, Hofmann M, Hors E, van den Berg F, Ponta H, Herrlich P, Pals ST: A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps. J Cell Biol 120: 227–233, 1993
Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA: Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell 52: 925–933, 1988
Dustin ML, Springer TA: Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. J Cell Biol 107: 321–331, 1988
Rothlein R, Dustin ML, Marlin SD, Springer TA: A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 137: 1270–1274, 1986
Johnson JP, Stade BG, Holzmann B, Schwäble W, Riethmüller G:De novo expression of intercellular-adhesion molecule 1 in melanoma correlates with increased risk of metastasis. Proc Natl Acad Sci USA 86: 641–644, 1989
Hawley RG, Wang M-H, Fong AZC, Hawley TS: Association between ICAM-1 expression and metastasis capacity of murine B-cell hydridomas. Clin Exp Metastasis 11: 213–226, 1993
Natali P, Nicotra MR, Cavaliere R, Bigotti A, Romano G, Temponi M, Ferrone S: Differential expression of intercellular adhesion molecule 1 in primary and metastatic melanoma lesions. Cancer Res 50: 1271–1278, 1990
Vogetseder W, Feichtinger H, Schulz TF, Schwaeble W, Tabaczewski P, Mitterer M, Böck G, Marth C, Dapunt O, Mikuz G, Dierich MP: Expression of 7F7-antigen, a human adhesion molecule identical to intercellular adhesion molecule-1 (ICAM-1) in human carcinomas and their stromal fibroblasts. Int J Cancer 43: 768–773, 1989
Kelly CP, O'Keane JC, Orellana J, Schroy III PC, Yang S, Lamont JT, Brady HR: Human colon cancer cells express ICAM-1in vivo and support LFA-1-dependent lymphocyte adhesionin vitro. Am J Physiol 263: G864–870, 1992
Schwaeble W, Kerlin M, Meyer zum Büschenfelde K-H, Dippold W:de novo expression of intercellular adhesion molecule 1 (ICAM-1, CD54) in pancreas cancer. Int J Cancer 53: 328–333, 1993
Tomita Y, Nishiyama T, Watanabe H, Fujiwara M, Sato S: Expression of intercellular adhesion molecule-1 (ICAM-1) on renal-cell cancer: possible significance in host immune responses. Int J Cancer 46: 1001–1006, 1990
Kolbeck PC, Kareggia FF, Johansson SL, Grune MT, Taylor RJ: The relationship among tumor-infiltrating lymphocytes, histopathologic findings, and long-term clinical follow-up in renal cell carcinoma. Modern Pathol 5: 420–425, 1992
Gómez-morales M, Aluaro T, Muñoz M, Garcia Del Moral R, Aguilar D, Caballero T, Aneiros J: Diffuse sclerosing papillary carcinoma of the thyroid gland: immunohistochemical analysis of the local host immune response. Histopathol 18: 427–433, 1991
Stewart THM, Tsai S-CJ: The possible role of stromal cell stimulation in worsening the prognosis of a subset of patients with breast cancer. Clin Exp Metastasis 11: 295–305, 1993
Lichtmer RB, Belloni PN, Nicolson GL: Differential adhesion of metastatic rat mammary carcinoma cells to organ-derived microvessel endothelial cells and subendothelial matrix. Exp Cell Biol 57: 146–152, 1989
Doerr P, Zvibel I, Chiuten D, D'Olimpio J, Reid LM: Clonal growth of tumors on tissue-specific biomatrices and correlation with organ site specificity of metastases. Cancer Res 49: 384–392, 1989
Pauli BU, Lee C-L: Organ preference of metastasis the role of organ-specifically modulated endothelial cells. Lab Invest 58: 379–387, 1988
Albelda SM, Buck CA: Integrins and other cell adhesion molecules. FASEB J 4: 2868–2880, 1990
Ruoslahti E: Integrins. J Clin Invest 87: 1–5, 1991
Ruoslahti E, Pierschbacher MD: New perspectives in cell adhesion: RGD and integrins. Science 238: 491–497, 1987
Gehlsen KR, Argraves WS, Pierschbacher MD, Ruoslahti E: Inhibition ofin vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides. J Cell Biol 106: 925–930, 1988
Humphries MJ, Olden K, Yamada KM: A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science 233: 467–470, 1986
Saiki I, Iida J, Murata J, Ogawa R, Nishi N, Sugimura K, Tokura S, Azuma I: Inhibition of the metastasis of murine malignant melanoma by synthetic polymeric peptides containing core sequences of cell-adhesive molecules. Cancer Res 49: 3815–3822, 1989
McCarthy JB, Skubitz APN, Palm SL, Furcht LT: Metastasis inhibition of different tumor types by purified laminin fragments and a heparin-binding fragment of fibronectin. J Natl Cancer Inst 80: 108–116, 1988
Dedhar S, Saulnier R: Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes. J Cell Biol 110: 481–489, 1990
Yamada KM, Kennedy DW, Yamada SS, Gralnick H, Chen W-T, Akiyama SK: Monoclonal antibody and synthetic peptide inhibitors of human tumor cell migration. Cancer Res 50: 4485–4496, 1990
Fujita S, Suzuki H, Kinoshita M, Hirohashi S: Inhibition of cell attachment, invasion and metastasis of human carcinoma cells by anti-integrin β1 subunit antibody. Jpn J Cancer Res 83: 1317–1326, 1992
Chan BMC, Matsuura N, Takada Y, Zetter B, Hemler ME:In vitro andin vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science 251: 1600–1602, 1991
Giancotti FG, Ruoslahti E: Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of chinese hamster ovary cells. Cell 60: 849–859, 1990
Schreiner C, Fisher M, Hussein S, Juliano RL: Increased tumorigenicity of fibronectin receptor deficient chinese hamster ovary cell variants. Cancer Res 51: 1738–1740, 1991
Plantefaber LC, Hynes RO: Changes in integrin receptors on oncogenically transformed cells. Cell 56: 281–290, 1989
Peltonen JP, Larjava H, Jaakkola S, Gralnick H, Akiyama SK, Yamada SS, Yamada KM, Uitto J: Localization of integrin receptors for fibronectin, collagen, and laminin in human skin variable expression in basal and squamous cell carcinomas. J Clin Invest 84: 1916–1923, 1989
Koretz K, Schlag P, Boumsell L, Möller P: Expression of VLA-α2, VLA-α6, and VLA-β1 chains in normal musoca and adenomas of the colon, and in colon carcinomas and their liver metastases. Am J Pathol 138: 741–750, 1991
Pignatelli M, Smith MEF, Bodmer WF: Low expression of collagen receptors in moderate and poorly differentiated colorectal adenocarcinomas. Br J Cancer 61: 636–638, 1990
Korhonen M, Laitinen L, Ylänne J, Koukoulis GK, Quaranta V, Juusela H, Gould VE, Virtanen I: Integrin distribution in renal cell carcinomas of various grades of malignancy. Am J Pathol 141: 1161–1171, 1992
Kirchhofer D, Languino LR, Ruoslahti E, Pierschbacher MD: α2β1 integrins from different cell types show different binding specificities. J Biol Chem 265: 615–618, 1990
Lotz MM, Korzelius CA, Mercurio AM: Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of α6β4 and α2β1 integrins. Cell Regul 1: 249–257, 1990
Elices MJ, Urry LA, Hemler ME: Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by ARG-GLY-ASP peptide and by divalent cations. J Cell Biol 112: 169–181, 1991
Shimizu Y, van Seventer GA, Horgan KJ, Shaw S: Regulated expression and binding of three VLA(β1) integrin receptors on T cells. Nature 345: 250–253, 1990
Hemler ME, Crouse C, Sonnenberg A: Association of the VLA α6 subunit with a novel protein a possible alternative to the common VLA β1 subunit on certain cell lines. J Biol Chem 264: 6529–6535, 1989
Pignatelli M, Hanby AM, Stamp WH: Low expression of β1, α2 and α3 subunits of VLA integrins in malignant mammary tumours. J Pathol 165: 25–32, 1991
Zutter MM, Mazoujian G, Santoro SA: Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast. Am J Pathol 137: 863–870, 1990
Pignatelli M, Cardillo MR, Hanby A, Stamp GWH: Integrins and their accessory adhesion molecules in mammary carcinomas: loss of polarization in poorly differentiated tumors. Hum Pathol 23: 1159–1166, 1992
D'Ardenne AJ, Richman PI, Horton MA, McAuly AE, Jordan S: Co-ordinate expression of the alpha-6-integrin laminin receptor sub-unit and laminin in breast cancer. J Pathol 165: 213–220, 1991
Lampugnani MG, Resnati M, Dejana E, Marchisio PC: The role of integrins in the maintenance of endothelial monolayer integrity. J Cell Biol 112: 479–490, 1991
Roos E, Roossien FF: Involvement of leukocyte functionassociated antigen-1 (LAF-1) in the invasion of hepatocyte cultures by lymphoma and T-cell hybridoma cells. J Cell Biol 105: 553–559, 1987
Roossien FF, de Rijk D, Bikker A, Roos E: Involvement of LAF-1 in lymphoma invasion and metastasis demonstrated with LAF-1-deficient mutants. J Cell Biol 108: 1979–1985, 1989
Harning R, Myers C, Merluzzi VJ: Monoclonal antibodies to lymphocyte function-associated antigen-1 inhibit invasion of human lymphoma and metastasis of murine lymphoma. Clin Exp Metastasis 11: 337–342, 1993
Gasic GJ, Tuszynski GP, Gorelik E: Interaction of the hemostatic and immune systems in the metastatic spread of tumor cells. Int Rev Exp Pathol 29: 173–212, 1986
Gasic GJ, Gasic TB, Stewart CC: Antimetastatic effects associated with platelet reduction. Proc Natl Acad Sci USA 61: 46–52, 1968
Pearlstein E, Ambrogio C, Karpatkin S: Effect of antiplatelet antibody on the development of pulmonary metastases following injection of CT26 colon adenocarcinoma, Lewis lung carcinoma, and B16 amelanotic melanoma tumor cell into mice. Cancer Res 44: 3884–3887, 1984
Ugen KE, Mahalingam M, Klein PA, Kao K-J: Inhibition of tumor cell-induced platelet aggregation and experimental tumor metastasis by the synthetic Gly-Arg-Gly-Asp-Ser peptide. J Natl Cancer Inst 80: 1461–1466, 1988
Menter DG, Sloane BF, Steinert BW, Onoda J, Craig R, Harkins C, Taylor JD, Honn KV: Platelet enhancement of tumor cell adhesion to subendothelial matrix: role of platelet cytoskeleton and platelet membrane. J Natl Cancer Inst 79: 1077–1090, 1987
Schneider MR, Schirner M: Antimetastatic prostacyclin analogs. Drug Fut 18: 29–48, 1993
McCulloch P, George WD: Warfarin inhibits metastasis of Mtln 3 rat mammary carcinoma without affecting primary tumour growth. Br J Cancer 59: 179–183, 1989
Moncada S, Korbut R, Bunting S, Vane JR: Prostacyclin is a circulating hormone. Nature 273: 767–768, 1978
Boukerche H, Berthier-Vergnes O, Tabone E, Doré J-F, Leung LLK, McGregor JL: Platelet-melanoma cell interaction is mediated by the glycoprotein IIb-IIIa complex. Blood 74: 658–663, 1989
McGregor BC, McGregor JL, Weiss LM, Wood GS, Hu C-H, Boukerche H, Warnke RA: Presence of cytoadhesins (IIb-IIIa-like glycoproteins) on human metastatic melanomas but not on benign melanocytes. Am J Clin Pathol 92: 495–499, 1989
Boukerche H, Berthier-Vergnes O, Bailly M, Doré JF, Leung LLK, McGregor JL: A monoclonal antibody (LYP-18) directed against the blood platelet glycoprotein IIb/IIIa complex inhibits human melanoma growthin vivo. Blood 74: 909–912, 1989
Albelda SM, Mette SA, Elder DE, Stewart R, Damjanovich L, Herlyn M, Buck CA: Integrin distribution in malignant melanoma: association of the β3 subunit with tumor progression. Cancer Res 50: 6757–6764, 1990
Nip J, Shibata H, Loskutoff DJ, Cheresh DA, Brodt P: Human melanoma cells derived from lymphatic metastases use integrin αvβ3 to adhere to lymph node vitronectin. J Clin Invest 90: 1406–1413, 1992
Kennel SJ, Foote LJ, Falcioni R, Sonnenberg A, Stringer CD, Crouse C, Hemler ME: Analysis of the tumor-associated antigen TSP-180 identity with α6β4 in the integrin superfamily. J Biol Chem 264: 15515–15521, 1989
Falcioni R, Kennel SJ, Giacomini P, Sacchi A: Expression of tumor antigen correlated with metastatic potential of Lewis lung carcinoma and B16 melanoma clones in mice. Cancer Res 46: 5772–5778, 1986
Falcioni R, Sacchi A, Resau J, Kennel SJ: Monoclonal antibody to human carcinoma-associated protein complex: quantitation in normal and tumor tissue. Cancer Res 48: 816–821, 1988
Kimmel KA, Carey TE: Altered expression in squamous carcinoma cells of an orientation restricted epithelial antigen detected by monoclonal antibody A9. Cancer Res 46: 3614–3623, 1986
Costantini RM, Falcioni R, Battista P, Zupi G, Kennel SJ, Colasante A, Venturo I, Curcio CG, Sacchi A: Integrin (α6/β4) expression in human lung cancer as monitored by specific monoclonal antibodies. Cancer Res 50: 6107–6112, 1990
Wolf GT, Carey TE, Schmaltz SP, McClatchey KD, Poore J, Glaser L, Hayashida DJS, Hsu S: Altered antigen expression predicts outcome in squamous cell carcinoma of the head and neck. J Natl Cancer Inst 82: 1566–1572, 1990
Kemperman H, Wijnands Y, de Rijk D, Roos E: The integrin α6β4 on TA3/Ha mammary carcinoma cells is involved in adhesion to hepatocytes. Cancer Res 53: 3611–3617, 1993
Roos E, Dingemans KP, van de Pavert IV, van den Bergh-Weerman MA: Mammary-carcinoma cells in mouse liver: infiltration of liver tissue and interaction with Kupffer cells. Br J Cancer 38: 88–99, 1978
Natali PG, Nicotra MR, Botti C, Mottolese M, Bigotti A, Segatto O: Changes in expression of α6/β4 integrin heterodimer in primary and metastatic breast cancer. Br J Cancer 318-322, 1992
Sonnenberg A, Calafat J, Janssen H, Daams H, van der Raaij-Helmer LMH, Falconi R, Kennel SJ, Aplin JD, Baker J, Loizidou M, Garrod D: Integrin α6/β4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion. J Cell Biol 113: 907–917, 1991
Waes CV, Kozarsky KF, Warren AB, Kidd L, Paugh D, Liebert M, Carey TE: The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin α6β4. Cancer Res 51: 2395–2402, 1991
Hunt G: The role of laminin in cancer invasion and metastasis. Exp Cell Biol 57: 165–176, 1989
Timpl R, Rohde H, Robey PG, Rennard SI, Foidart J-M, Martin GR: Laminin - a glycoprotein from basement membrane. J Biol Chem 254: 9933–9937, 1979
Albini A, Aukerman SL, Ogle RC, Noonan DM, Fridman R, Martin GR, Fidler IJ: Thein vitro invasiveness and interactions with laminin of K-1735 melanoma cells evidence for different laminin-binding affinities in high and low metastatic variants. Clin Exp Metastasis 7: 437–451, 1989
Wewer UM, Taraboletti G, Sobel ME, Albrechtsen R, Liotta LA: Role of laminin receptor in tumor cell migration. Cancer Res 47: 5691–5698, 1987
Cioce V, Castronovo V, Shmookler BM, Garbisa S, Grigioni WF, Liotta LA, Sobel ME: Increased expression of the laminin receptor in human colon cancer. J Natl Cancer Inst 83: 29–36, 1991
Satoh S, Narumi K, Isemura M, Sakai T, Abe T, Matsushima K, Okuda K, Motomiya M: Increased expression of the 67 kDa-laminin receptor gene in human small cell lung cancer. Biochem Biophys Res Comm 182: 746–752, 1992
Aliño SF, Unda FJ, Pérez-Yarza G: Laminin surface binding sites and metastatic potential of 3LL tumor cells increased by indomethacin. Biochem Biophys Res Comm 167: 731–738, 1990
Graf J, Iwamoto Y, Sasaki M, Martin GR, Kleinman HK, Robey FA, Yamada Y: Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding. Cell 48: 989–996, 1987
Iwamoto Y, Robey FA, Graf J, Sasaki M, Kleinman HK, Yamada Y, Martin GR: YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation. Science 238: 1132–1134, 1987
Nomizu M, Yamamura K, Kleinman HK, Yamada Y: Multimeric forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide enhance the inhibition of tumor growth and metastasis. Cancer Res 53: 3459–3461, 1993
Castronovo V, Colin C, Claysmith AP, Chen PHS, Lifrange E, Lambotte R, Krutzsch H, Liotta LA, Sobel ME: Immunodetection of the metastasis-associated laminin receptor in human breast cancer cells obtained by fine-needle aspiration biopsy. Am J Pathol 137: 1373–1381, 1990
Martignone S, Pellegrini R, Villa E, Tandon NN, Mastroianni A, Tagliabue E, Ménard S, Colnaghi MI: Characterization of two monoclonal antibodies directed against the 67 kDa high affinity laminin receptor and application for the study of breast carcinoma progression. Clin Exp Metastasis 10: 379–386, 1992
Liotta LA, Rao CN: Tumor invasion and metastasis. Monogr Pathol 27: 183–192, 1986
Shi YE, Torri J, Yieh L, Sobel ME, Yamada Y, Lippman ME, Dickson RB, Thompson EW: Expression of 67 kDa laminin receptor in human breast cancer cells: regulation by progestins. Clin Exp Metastasis 11: 251–261, 1993
Castronovo V, Taraboletti G, Liotta LA, Sobel ME: Modulation of laminin receptor expression by estrogen and progestins in human breast cancer cell lines. J Natl Cancer Inst 81: 781–788, 1989
Hrushesky WJM: Breast cancer and the menstrual cycle. J Surg Oncol 53: 1–3, 1993
Martignone S, Ménard S, Bufalino R, Cascinelli N, Pellegrini R, Tagliabue E, Andreola S, Rilke F, Colnaghi MI: Prognostic significance of the 67-kilodalton laminin receptor expression in human breast carcinomas. J Natl Cancer Inst 85: 398–402, 1993
Marques LA, Franco ELF, Torloni H, Brentani MM, da Silva-Neto JB, Brentani RR: Independent prognostic values of laminin receptor expression in breast cancer survival. Cancer Res 50: 1479–1483, 1990
Daidone MG, Silvestrini R, D'Errico A, Di Fronzo G, Benini E, Mancini AM, Garbisa S, Liotta LA, Grigioni WF: Laminin receptors, collagenase IV and prognosis in nodenegative breast cancers. Int J Cancer 48: 529–532, 1991
Malinoff HL, McCoy Jr JP, Varani J, Wicha MS: Metastatic potential of murine fibrosarcoma cells is influenced by cell surface laminin. Int J Cancer 33: 651–655, 1984
Terranova VP, Williams JE, Liotta LA, Martin GR: Modulation of the metastatic activity of melanoma cells by laminin and fibronectin. Science 226: 982–985, 1984
Kanemoto T, Reich R, Royce L, Greatorex D, Adler SH, Shiraishi N, Martin GR, Yamada Y, Kleinman HK: Identification of an amino acid sequence from the laminin A chain that stimulates metastasis and collagenase IV production. Proc Natl Acad Sci USA 87: 2279–2283, 1990
Sakamoto N, Iwahana M, Tanaka NG, Osada Y: Inhibition of angiogenesis and tumor growth by a synthetic laminin peptide, CDPGYIGSR-NH2. Cancer Res 51: 903–906, 1991
Kleinman HK, Cannon FB, Laurie GW, Hassell JR, Aumailley M, Terranova VP, Martin GR, DuBois-Dalcq M: Biological activities of laminin. J Cell Biochem 27: 317–325, 1985
Turpeenniemi-Hujanen T, Thorgeirsson UP, Rao CN, Liotta LA: Laminin increases the release of type IV collagenase from malignant cells. J Biol Chem 261: 1883–1889, 1986
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Maemura, M., Dickson, R.B. Are cellular adhesion molecules involved in the metastasis of breast cancer?. Breast Cancer Res Tr 32, 239–260 (1994). https://doi.org/10.1007/BF00666002
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DOI: https://doi.org/10.1007/BF00666002