Abstract
The complex forming ability of a water-soluble β-cyclodextrin epichlorohydrin, polymer (CDPS) and its different molecular weight fractions was studied and compared with the complexing properties of β-cyclodextrin (βCD) and dimethyl-βCD (DM-βCD). CDPS was separated into two main fractions. CDPS and its fractions formed well soluble inclusion compounds with the studied drugs. The low molecular weight fraction formed rather stable complexes with small guest molecules, the high molecular weight fraction was found to be more efficient in binding larger substrates. Structural studies of furosemide-CD complexes were attempted by NMR spectroscopy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
N. Wiedenhof, J. N. J. J. Lammers, and C. L. van Panthaleon van Eck:Stärke 21, 119 (1969).
A. Harada, M. Furue, and S. Nozakura:Polymer J 13, 777 (1981).
É. Fenyvesi, M. Szilasi, B. Zsadon, J. Szejtli, and F. Tüdős:Proceeding of the Ist International Symposium on Cyclodextrins (Ed.: J. Szejtli), pp. 345–356, D. Reidel Publishing Co., Dordrecht, Holland, 1982.
K. Uekama, M. Otagiri, T. Irie, H. Seo, and M. Tsuruoka:Int. J. Pharm. 23, 35 (1985).
J. Pitha and Jan Pitha:J. Pharm. Sci. 47, 987 (1985).
J. Pitha, S. M. Harman, and M. E. Michel:J. Pharm. Sci. 75, 165 (1986).
T. Higuchi and K. A. Connors:Adv. Anal. Chem. Instr. 4, 117 (1965).
K. A. Connors and T. W. Rosanske:J. Pharm. Sci. 69, 173 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Szeman, J., Fenyvesi, E., Szejtli, J. et al. Water soluble cyclodextrin polymers: Their interaction with drugs. Journal of Inclusion Phenomena 5, 427–431 (1987). https://doi.org/10.1007/BF00664098
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00664098