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Comparative mapping ofIGHG, IGHM, FES, andFOS in domestic cattle

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Abstract

The immunoglobulin genes have not been genetically characterized as thoroughly in cattle as in other mammals, particularly humans and mice. Comparative gene mapping in mammals suggests that the bovine immunoglobulin heavy chain genes,IGHG4 andIGHM might be syntenic with theFOS oncogene. Interestingly, however, when these genes were assigned to bovine syntenic groups utilizing a panel of bovine: hamster hybrid somatic cells,IGH genes were shown to be syntenic with theFES oncogene rather thanFOS. In this studyIGH andFES were assigned toBos taurus chromosome 21 whileFOS was assigned to chromosome 10. In addition, bovine-specific immunoglobulin-like sequences were observed in the hybrid somatic cells, and one, IGHML1, was mapped to bovine syntenic group U16. The probes used for somatic-cell mapping were also used to screen a small number of cattle of several different breeds for restriction fragment length polymorphisms.IGHG4 andIGHM were shown to be highly polymorphisms. whileFOS andFES were not.

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  1. Department of Veterinary Pathobiology, Texas A & M University, 77843, College Station, TX, USA

    Tammy C. Tobin-Janzen & James E. Womack

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Tobin-Janzen, T.C., Womack, J.E. Comparative mapping ofIGHG, IGHM, FES, andFOS in domestic cattle. Immunogenetics 36, 157–165 (1992). https://doi.org/10.1007/BF00661092

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