Skip to main content
SpringerLink
Log in

Competitive adsorption of fibrinogen and albumin onto polymer microspheres having hydrophilic/hydrophobic heterogeneous surface structures

  • Original Contributions
  • Published:
Colloid and Polymer Science Aims and scope Submit manuscript

Abstract

The competitive adsorption of bovine fibrinogen (BFb) and bovine serum albumin onto polymer microspheres from the mixture solution was examined under various protein-to-microsphere ratios using various homopolymer microspheres and poly(2-hydroxyethyl methacrylate)/polystyrene composite microspheres having heterogeneous surface structures consisting of both hydrophilic and hydrophobic parts. They were produced by emulsifier-free (seeded) emulsion polymerizations. The selective adsorption of BFb was not observed for the homopolymer microspheres, but observed for the composite polymer microspheres having optimum compositions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Singer JM, Plotz CM (1956) AM J Med 20:888

    Google Scholar 

  2. Grinbnau TCJ, Leuvering JHW, Hell van H (1976) J Chromatog Biomedical Appl 376:565

    Google Scholar 

  3. Zsom RLJ (1986) J Colloid Interface Sci 111:434

    Google Scholar 

  4. Okubo M, Azuma I, Yamamoto Y (1990) Colloid Polym Sci 268:598

    Google Scholar 

  5. Okubo M, Azuma I, Hattori H, Trends in Polym Sci (in press)

  6. Okubo M, Azuma I, Hattori H (1992) J Appl Polym Sci 45:245

    Google Scholar 

  7. Matsumoto T, Okubo M, Imai T (1975) Kobunshi Ronbunshu 32:229

    Google Scholar 

  8. Matsumoto T, Okubo M, Onoe S (1976) Kobunshi Ronbunshu 33:565

    Google Scholar 

  9. Matsumoto T, Okubo M, Shibao S (1977) Kobunshi Ronbunshu 34:557

    Google Scholar 

  10. Okubo M, Yamada A, Matsumoto T (1981) J Polym Sci Polym Chem 19:1

    Google Scholar 

  11. Vijayendran BR, In: Fitch M (ed) Polymer Colloid II. Plenum Press, New York, p 209

  12. Okubo M, Yamamoto Y, Kamei S (1989) Colloid Polym Sci 267:861

    Google Scholar 

  13. Lensen HGW, Breehaar W, Smolders CA (1986) J Chromatogr Biomedical Appl 376:191

    Google Scholar 

  14. Kamei S, Okubo M, Matsumoto T (1987) J Appl Polym Sci 34:1439

    Google Scholar 

  15. Fair BD, Jamieson AM (1980) J Colloid Interface Sci 77:525

    Google Scholar 

  16. Mihalyi E (1965) Biochim Biophys Acta 102:487

    Google Scholar 

  17. Okubo M, Kamei S, Mori K, Matsumoto T (1983) Kobunshi Ronbunshu 40:449

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Rokko, 657, Nada, Kobe, Japan

    M. Okubo & H. Hattori

Authors
  1. M. Okubo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Hattori
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Part CXXXVIII on the series “Studies on Suspension and Emulsion’

Rights and permissions

Reprints and permissions

About this article

Cite this article

Okubo, M., Hattori, H. Competitive adsorption of fibrinogen and albumin onto polymer microspheres having hydrophilic/hydrophobic heterogeneous surface structures. Colloid Polym Sci 271, 1157–1164 (1993). https://doi.org/10.1007/BF00657071

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00657071

Key words

Search

Navigation