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Hepatic arterial chemotherapy for primary and metastatic liver cancers

  • First International Symposium on Treatment of Liver Cancer Kobe, Japan, 15–16 November 1987 Session 2: Chemotherapy, Immunotherapy and Radiotherapy
  • Hepatic Arterial Chemotherapy, Metastatic Liver Cancer
  • Published:
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Summary

Hepatic arterial chemotherapy represents a means of selectively exposing hepatic tumor to cytotoxic agents. Although 5-fluoro-2′-deoxyuridine has been shown to generate a higher response rate in the treatment of colorectal liver metastases than that achieved by intravenous infusion, responses are largely incomplete and rarely of long duration. This review describes the rationale for the use of the thymidine analogs 5-bromo-2′-deoxyuridine and 5-iodo-2′-deoxyuridine in hepatic arterial infusions and indicates how combination therapy adding radiotherapy, specifically with hepatic arterially administered yttrium-90 microspheres, might generate a new, more efficient and effective therapeutic approach.

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Authors and Affiliations

  1. Upjohn Center for Clinical Pharmacology, Department of Medicine, University of Michigan Medical School, 48109, Ann Arbor, Michigan, USA

    William Ensminger

  2. Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, Michigan, USA

    William Ensminger

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  1. William Ensminger
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Ensminger, W. Hepatic arterial chemotherapy for primary and metastatic liver cancers. Cancer Chemother. Pharmacol. 23 (Suppl 1), S68–S73 (1989). https://doi.org/10.1007/BF00647244

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  • DOI: https://doi.org/10.1007/BF00647244

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