Summary
Serum zinc and copper levels were studied in relation to in vitro and in vivo drug metabolism in 25 alcoholics, in whom various diseases of the liver had been diagnosed by histology. Serum zinc was elevated in alcoholics with normal or fatty liver and was low in those with alcoholic hepatitis or cirrhosis. There was a significant positive correlation between serum zinc and cytochrome P-450 content of liver biopsies. The relationship between zinc and antipyrine half-life was significant and non-linear. Serum copper level was elevated in all the alcoholics and no significant relationship could be found between copper and drug metabolism in alcoholics. The findings suggest parallelism between changes in serum zinc and indices of drug metabolism in alcoholics.
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References
Becking, G. C., Morrison, A. B.: Hepatic drug metabolism in zinc-deficient rats. Biochem. Pharmacol.19, 895–902 (1970)
Becking, G. C.: Trace elements and drug metabolism. Med. Clin. North Amer.60, 813–830 (1976)
Moffitt, A. E., Jr., Murphy, S. D.: Effect of excess and deficient copper intake on rat liver microsomal enzyme activity. Biochem. Pharmacol.22, 1463–1476 (1973)
Peters, M. A., Fonts, J. R.: The influence of magnesium and some other divalent cations on hepatic microsomal drug metabolism in vitro. Biochem. Pharmacol.19, 533–544 (1970)
Prasad, A. S., Miale, A., Jr., Farid, Z., Sanstead, H. H., Shulert, A. R.: Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism and hypogonadism. J. Lab. clin. Med.61, 537–549 (1963)
Menkes, J. H., Alter, M., Steigleder, G. K.: A sex-linked recessive disorder with retardation of growth, peculiar hair and focal cerebral and cerebellar degeneration. Pediatrics29, 764–779 (1962)
Vallee, B. L., Wacker, W. E. C., Bartholomay, A. F., Robin, E. D.: Zinc metabolism in hepatic dysfunction. I. Serum zinc concentration in Laennec's cirrhosis and their validation by sequential analysis. New Engl. J. Med.255, 403–408 (1956)
Halsted, J. A., Smith, J. C., Jr.: Plasma zinc in health and disease. Lancet1970 I, 322–324
Davies, I. J., Musa, M. and Dormandy, T. L.: Measurements of plasma zinc. Part I. In health and disease. J. clin. Pathol.21, 359–365 (1968)
Wolff, H.: Untersuchungen zur Pathophysiologie des Zinkstoffwechsels. Klin. Wschr.34, 409–418 (1956)
Hepner, G. W., Vesell, E. S.: Quantitative assessment of hepatic function by breach analysis after oral administration of (14C) aminopyrine. Ann. int. Med.83, 632–638 (1975)
Branch, R. A., Herbert, C. M., Read, A. F.: Determinants of serum antipyrine half-lives in patients with liver disease. Gut14, 569–573 (1973)
Conney, A. H., Garren, L.: Contrasting effects of thyroxin on zoxazolamine and hexobarbital metabolism. Biochem. Pharmacol.6, 257–262 (1961)
Brodie, B. B., Axelrod, J.: The fate of antipyrine in man. J. Pharmacol. exp. Ther.98, 97–104 (1950)
Sotaniemi, E. A., Kontturi, M. J., Larmi, T. K. I.: Drug metabolism and androgen control therapy in prostatic cancer. Clin. Pharmacol. Ther.14, 413–417 (1973)
Conney, A. H.: Pharmacological implications of microsomal enzyme induction. Pharmacol. Rev.19, 317–366 (1967)
Hackley, B. M., Smith, J. C., Halsted, J. A.: A simplified method for plasma zinc determination by atomic absorption spectrophotometry. Clin. Chem.14, 1–5 (1968)
Omura, T., Sato, R.: The carbon-monoxide binding pigment of liver microsomes. 1. Evidence of its hemoprotein nature. J. biol. Chem.239, 2370–2378 (1964)
Pelkonen, O., Kaltiala, E. H., Larmi, T. K. I., Kärki, N. T.: Cytochrome P-450 linked mono-oxygenase system and drug-induced spectral interactions in human liver microsomes. Chem.- Biol. Interact.9, 205–216 (1974)
Prescott, L. F., Adjepon-Yamok, K. K., Roberts, E.: Rapid gasliquid chromatographic estimation of antipyrine in plasma. J. Pharm. Pharmacol.25, 205–207 (1973)
Sotaniemi, E. A., Ahlqvist, J., Pelkonen, R. O., Pirttiaho, H., Luoma, P. V.: Liver parenchymal changes and indices of drug metabolism in alcoholics. Europ. J. clin. Pharmacol.II, 295–303 (1977)
Ahlqvist, J.: Transverse mounting of ribbons on groups of slides for comparing different stains in adjacent sections. Stain Technol.45, 38–39 (1970)
Ahlqvist, J.: Liver mast cell counts during development of cirrhosis of the liver in rats on a low protein, high fat diet. Acta Path. Microbiol. Scand. Suppl.142, 1–64 (1960)
Sass-Kortsak, A.: Copper metabolism. Adv. clin. Chem.8, 1–67 (1965)
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Hartoma, T.R., Sotaniemi, E.A., Pelkonen, O. et al. Serum zinc and serum copper and indices of drug metabolism in alcoholics. Eur J Clin Pharmacol 12, 147–151 (1977). https://doi.org/10.1007/BF00645136
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DOI: https://doi.org/10.1007/BF00645136