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Renal effects of bumetanide, a new saluretic agent

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Summary

The renal effects of bumetanide, a new diuretic chemically related to furosemide, have been studied in four young healthy volunteers during dehydration and water diuresis. Bumetanide produced a considerable diuresis due mainly to an increase in osmotic clearance. The peak urinary volume amounted to about 1/3 of the filtered volume, indicating an effect of the drug on the proximal tubule. Free water clearance was not significantly affected. During dehydration, with its superimposed osmotic diuresis, bumetanide diminished the concentrating power of the kidney so that an almost isotonic urine was produced. This result implied an additional effect on the distal parts of the nephron and it may represent partial blockade of sodium reabsorption in the ascending limb of the loop of Henle.

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Authors and Affiliations

  1. Department of Medicine I, Sahlgren's Hospital, University of Göteborg, Sweden

    S. -G. Karlander, R. Henning & O. Lundvall

  2. Department of Medicine, County Hospital of Jönkoping, Jönkoping, Sweden

    S. -G. Karlander, R. Henning & O. Lundvall

Authors
  1. S. -G. Karlander
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  2. R. Henning
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  3. O. Lundvall
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Karlander, S.G., Henning, R. & Lundvall, O. Renal effects of bumetanide, a new saluretic agent. Eur J Clin Pharmacol 6, 220–223 (1973). https://doi.org/10.1007/BF00644735

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  • DOI: https://doi.org/10.1007/BF00644735

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