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Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline

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Summary

Hydrochlorothiazide 75 mg was given twice p.o. to fasting subjects. In the second study they had been pretreated with propantheline 60 mg. Plasma and urine concentrations of hydrochlorothiazide were determined by GLC. Pretreatment with propantheline on average delayed the maximal plasma level of hct from 2.4 to 4.8 h (p<0.05); and the total urinary recovery of hydrochlorothiazide by 48 h was increased from 49.3 mg to 66.9 mg (p<0.005). It was concluded that propantheline increased substantially the absorption of the diuretic.

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References

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Authors and Affiliations

  1. Department of Medicine and Clinical Pharmacology Laboratory, Serafimerlasarettet, Stockholm, Sweden

    B. Beermann & Margaretha Groschinsky-Grind

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  1. B. Beermann
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  2. Margaretha Groschinsky-Grind
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Supported by the Swedish Medical Research Council (Grant No. B78-19X-00227-14)

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Beermann, B., Groschinsky-Grind, M. Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline. Eur J Clin Pharmacol 13, 385–387 (1978). https://doi.org/10.1007/BF00644613

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  • DOI: https://doi.org/10.1007/BF00644613

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