Summary
Biosprolol is a new beta1-selective beta-blocking agent with a plasma half-time of 10–12 h and without partial agonist properties.
Forty-eight patients with essential hypertension were randomly treated with 5, 10, or 20 mg bisoprolol given once daily for 8 weeks. All measurements were made 24 hours after the last dose.
Bisoprolol had antihypertensive and beta-blocking properties both at rest and during exercise. The 20 mg dosage regimen was more effective than that of 5 mg and 10 mg.
The drug was well tolerated and all the 48 patients completed the trial.
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Weiner, L., Frithz, G. Antihypertensive effects of bisoprolol during once daily administration in patients with essential hypertension. Eur J Clin Pharmacol 29, 517–521 (1986). https://doi.org/10.1007/BF00635886
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DOI: https://doi.org/10.1007/BF00635886