Summary
Rat iris, which is richly innervated by adrenergic nerves, was incubated with3H-noradrenaline (3H-NA) in plasma from patients receiving clinical treatment with chlorpromazine, thioridazine, opipramol, chlorprothixene, trifluoperazine and haloperidol. The uptake of3H-NA by the iris was compared with that found in control samples of plasma. Chlorpromazine significantly inhibited the uptake of3H-NA; no effect on NA uptake was found in plasma from patients on lithium, opipramol or the other neuroleptic drugs, i. e. only clinical doses of chlorpromazine and tricyclic antidepressant drugs inhibited neuronal NA uptake. A cross-over study of nortriptyline and amitriptyline (50 mg t.i.d.) was performed in 6 patients. Both the plasma concentrations of nortriptyline (the main metabolite of amitriptyline) and the inhibition of NA uptake in the rat iris were greater when the patients were taking nortriptyline.
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Tuck, J.R., Hamberger, B. & Sjöqvist, F. Uptake of3H-noradrenaline by adrenergic nerves of rat iris incubated in plasma from patients treated with various psychotropic drugs. Eur J Clin Pharmacol 4, 212–216 (1972). https://doi.org/10.1007/BF00635798
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DOI: https://doi.org/10.1007/BF00635798