Skip to main content
SpringerLink
Log in

Usefulness of fibrin glue in oncologic plastic surgery

  • Originals
  • Published:
European Journal of Plastic Surgery Aims and scope Submit manuscript

Summary

Human fibrin glue (Tissucol) is a plasma-derived compound endowed with adhesive and hemostatic properties and possessing a specific local anti-infection function mediated through activation of nonspecific immunity elements. The aim of this study is to show that in patients who have undergone prolonged reconstructive plastic surgery following cancer resection, Tissucol decreases infectious complications as compared to a control group. Between June 1985 and February 1988, 51 subjects were treated with fibrin glue during reconstruction operations. Analysis of the results showed that Tissucol produced a statistically significant reduction both of immediate complications, such as inflammation and partial separation of the surgical wound, and of delayed complications, such as scar hypertrophy and cutaneous fistulae. In conclusion, patients treated with Tissucol showed a better quality of surgical wound, a more rapid postoperative functional recovery and consequently a decrease in the duration of hospitalization.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aach RD, Szmuness W, Mosley JW et al (1981) Serum alanine aminotransferase of donors in relation to the risk of non-A, non-B hepatitis in recipients. N Engl J Med 304:989

    Google Scholar 

  2. Bosch P (1980) Experimental investigation of the effect of fibrin adhesive graft. Arch Orthop Trauma Surg 96:177

    Google Scholar 

  3. Brandstetdt S, Rank F, Olson PS (1980) Wound healing and formation of granulation tissue in normal and defibrinogenated rabbits. An experimental model and histological study. Eur Sur Res 12:12

    Google Scholar 

  4. Bruster HT, Juntz BME, Scheja JW (1988) Autovaccination plus heat-inactivated autologous plasma in AIDS patients. Lancet 1:1284

    Google Scholar 

  5. Cronkite EP, Lozner EL, Deaver JM (1944) Use of thrombin and fibrinogen in skin grafting. J Am Med Assoc 124:976

    Google Scholar 

  6. Donati L (1986) Indicazioni e limiti della colla di fibrina (Tissucol) in chirurgia plastica. Proceedings of the XXXV Conference of the Italian Society of Plastic Surgery; Milan, September 25–27, 1986. In: La colla di fibrina (Tissucol) in chirurgia plastica. Monduzzi, Milan, p 51

    Google Scholar 

  7. Eder G, Neumann M, Cerwenka R, Baumgarten K (1986) Preliminary results of a randomized controlled study on the risk of hepatitis transmission of a two-component fibrin sealant (Tissucol/Tisseel). In: Schlag G, Redl H (eds) Fibrin sealant in operative medicine. Springer, Berlin, 7:51

    Google Scholar 

  8. Germani G (1982) Utilizzazione della colla di fibrina in chirurgia plastica. Riv It Chir Plast 1:443

    Google Scholar 

  9. Hedelin H, Lundholm K, Teger-Nilsson AC et al (1983) Influence of local fibrin deposition on granulation tissue formation. A biochemical study in the rat. Eur Surg Res 15:312

    Google Scholar 

  10. Hornbrook MC, Dood RY, Jacobs P et al (1982) Reducing the incidence of non-A, non-B post-transfusion hepatitis by testing donor blood for alanine aminotransferase. N Engl J Med 307:1315

    Google Scholar 

  11. Hunt TK, Knighton DR, Thakral KK et al (1984) Studies on inflammation and wound healing: angiogenesis and collagen synthesis stimulated in vivo by resident and activated wound macrophages. Surgery 86:48

    Google Scholar 

  12. Kasai S, Kunimoto R, Nitta K (1983) Cross-linking of fibrin by activated factor XIII stimulates attachment, morphological changes and proliferation of fibroblast. Biomed Res 4:155

    Google Scholar 

  13. Matras H (1982) The use of fibrin sealant in oral and maxillofacial surgery. J Oral Maxillofac Surg 40:617

    Google Scholar 

  14. Rousou J, Gonzales-Lavin J, Cosgrove D et al (1989) Randomized clinical trial of fibrin sealant in patients undergoing resternotomy or reoperation after cardiac operations. J Thorac Cardiovasc Surg 97:194

    Google Scholar 

  15. Schricker KT, Scheele J (1981) Hepatitisrisiko der Fibrinklebung in der Allgemeinchirurgie. Med Welt 32:783

    Google Scholar 

  16. Spangler HP (1976) Tissue adhesion and local hemostasis fibrinogen, thrombin and clotting factor XIII (experimental investigation-clinical experience). Wien Klin Wochenschr 88 [Suppl 49]:3

    Google Scholar 

  17. Staindl O (1982) The fibrin-adhesive system in plastic surgery of head and neck. J Head Neck Pathol 3:78

    Google Scholar 

  18. Staindl O (1979) The healing of wounds and scar formation under the influence of a tissue adhesion system with fibrinogen, thrombin and coagulation factor XIII. Arch Otorhinolaryngol 222:241

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Plastic Surgery Division, Instituto Nazionale Tumori, Via Venezian, 1, I-20133, Milan, Italy

    T. Fabrizio, M. Nava, N. Arioli & A. Grisotti

Authors
  1. T. Fabrizio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Nava
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Arioli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Grisotti
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fabrizio, T., Nava, M., Arioli, N. et al. Usefulness of fibrin glue in oncologic plastic surgery. Eur J Plast Surg 13, 201–205 (1990). https://doi.org/10.1007/BF00634569

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00634569

Key words

Search

Navigation