Abstract
Adult male volunteers with a prior history of either moderate (N=12) or heavy (N=14) marihuana use were systematically observed before, during and after a 21-day period of free access to 1 g 2% delta-9 THC marihuana cigarettes. A matched sample of casual alcohol drinkers (N=11) served as a control group. Sleep and other molar behaviors were observed hourly to obtain a representative sample of daily activity.
Both moderate and heavy users were less active immediately after marihuana use and slept more on days following heavier consumption. Heavy users reduced their waking activity on days following heavier consumption, as well as during the entire period of marihuana availability. These reactions did not persist beyond the period of availability for either group.
The findings suggest a dose-related delayed reaction to heavy marihuana consumption which disappears following the cessation of regular use. However, changes in activity following single doses of marihuana may be related more to the social circumstances of its use than to its pharmacological action.
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References
Allentuck, S., Bowman, K. M.: The psychiatric aspects of marihuana intoxication. Amer. J. Psychiat.99, 248–251 (1942)
Babor, T. F., Mendelson, J. H., Greenberg, I., Kuehnle, J. C.: Marihuana consumption and tolerance to physiological and subjective effects. Arch. gen. Psychiat.32, 1548–1552 (1975)
Bowman, M., Pihl, R. O.: Cannabis: Psychological effects of chronic heavy use. Psychopharmacologia (Berl.)29, 159–170 (1973)
Brobeck, J. R.: Regulation of energy exchange. In: Physiology and biophysics, T. C. Ruch and H. D. Patton, eds., pp. 1022–1029 Philadelphia: Saunders 1965
Brown, A.: Possible anticholinesterase-like effects of trans (-) Δ8 and Δ9-tetrahydrocannabinol as observed in the general motor activity of mice. Psychopharmacologia (Berl.)27, 111–116 (1972)
Brown, A. C., Brengelmann, G.: Energy metabolism. In: Physiology and biophysics, T. C. Ruch and H. D. Patton, eds., pp. 1030–1045 Philadelphia: Saunders 1965
Greenberg, I., Mendelson, J. H., Kuehnle, J. C., Mello, N. K.: Psychiatric and behavioral observations of causal and heavy marihuana users in a controlled research setting. Ann. N.Y. Acad. Sci. (in press)
Griffiths, R., Bigelow, G., Liebson, I.: Assessment of effects of ethanol self-administration on social interactions in alcoholics. Psychopharmacologia (Berl.)38, 105–110 (1974)
Hochman, J. S., Brill, N. Q.: Chronic marihuana use and psychosocial adaptation. Amer. J. Psychiat.130, 132–140 (1973)
Hollingshead, A. B., Redlich, F. C.: Social class and mental illness: a community study. New York: John Wiley 1958
Kupfer, D. J., Detre, T., Koral, J., Fajans, P.: A comment on the ‘amotivational syndrome’ in marihuana smokers. Amer. J. Psychiat.130, 1319–1322 (1973)
Masur, J., Martz, R. M., Carlini, E. A.: Effects of acute and chronic administration of cannabis sativa and (-) Δ9-transtetrahydrocannabinol on the behavior of rats in an open field. Psychopharmacologia (Berl.)19, 388–397 (1971)
McGlothlin, W. H.: The use of cannabis: East and West. In: Biomedical and pharmacological aspects of dependence, pp. 167–193. Haarlem, The Netherlands: Bohn and Vitgeuers 1971
McGlothlin, W. H., West, L. J.: The marihuana problem: An overview. Amer. J. Psychiat.125, 126–134 (1968)
Mendelson, J. H., Kuehnle, J. C., Ellingboe, J., Babor, F. T.: Plasma testosterone levels prior to, during and following chronic marihuana smoking. New Engl. J. Med.291, 1051–1055 (1974)
Mendelson, J. H., Kuehnle, J. C., Greenberg, I., Mello, N. K.: Operant acquisition of marihuana in man. J. Pharmacol. exp. Ther. (in press)
Mendelson, J. H., Rossi, A. M., Meyer, R. E., eds., The Use of Marihuana: A Psychological and Physiological Inquiry. New York: Plenum Publishing Corp. 1974
Miles, C. G., Congreve, G. R., Gibbins, R. J., Marshman, J., Devenyi, P., Hicks, R. C.: An experimental study of the effects of daily cannabis smoking on behavior patterns. Acta pharmacol. (Kbh.)34, 1–44 (1974)
Miller, L. L., Drew, W. G.: Cannabis: Review of behavioral effects in animals. Psychol. Bull.81, 401–417 (1974)
Nahas, G.: Clinical pharmacology of cannabis sativa with special reference to delta-9-THC. Bull. Narc.25, 9–39 (1973)
Orcutt, J. D., Biggs, D. A.: Recreational effects of marihuana and alcohol: Some descriptive dimensions. Int. J. Addict.10, 229–239 (1975a)
Orcutt, J. D., Biggs, D. A.: Testing a sociological theory of recreational drug effects. Sociology Soc. Res.59, 136–149 (1975b)
Passmore, R., Durnin, J. V. G.: Human energy expenditure. J. Physiol. Rev.35, 801–840 (1955)
Rossi, A. M., Bernstein, J. G., Mendelson, J. H.: Sleep-wakefulness behavior. In: The use of marihuana: A psychological inquiry, J. H. Mendelson, A. M. Rossi, and R. E. Meyer, eds., Ch. 13. New York: Plenum Press 1974
Rubin, V., Comitas, L.: Ganja in Jamaica: A medical anthropological study of chronic marihuana use. The Hague: Mouton 1975
Scheckel, C. L., Boff, E., Dahlen, P., Smary, T.: Behavioral effects in monkeys of racemates of two biologically active marihuana constituents. Science160, 1467–1469 (1968)
Soueif, M. I.: Hashish consumption in Egypt with special reference to psychological aspects. U.N. Bull. Narc.19, 1–12 (1967)
Stefanis, C., Dornbush, R., Fink, M.: Chronic hashish use. New York: Raven Press 1975
Walton, R. P.: Marihuana, America's new drug problem. Philadelphia: Lippincott 1938
Williams, E. G., Himmelsbach, C. K., Wikler, A., Ruble, D. C.: Studies on marihuana and pyrahexyl compound. Publ. Hlth Rep.61, 1059–1083 (1946)
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Babor, T.F., Mendelson, J.H. & Kuehnle, J. Marihuana and human physical activity. Psychopharmacology 50, 11–19 (1976). https://doi.org/10.1007/BF00634148
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DOI: https://doi.org/10.1007/BF00634148