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History and genealogy of theH-2K b mutants from the C57BL/6Kh colony

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Abstract

The genealogy of 14H-2K b mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of their sibs and ancestors strongly indicate that they represent recurring mutational events rather than the segregation of a single mutation throughout the colony.

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Authors and Affiliations

  1. Section of Medical Oncology, Departments of Medicine and Microbiology-Immunology and the Cancer Center, Northwestern University Medical School, 303 East Chicago Avenue, 60611, Chicago, Illinois

    Roger W. Melvold

  2. Department of Radiation Therapy, Harvard Medical School and Shields Warren Radiation Laboratory, New England Deaconess Hospital, 50 Binney Street, 02115, Boston, Massachusetts

    Roger W. Melvold, Henry I. Kohn & Gary R. Dunn

  3. Bioassay Systems, Inc., 225 Wildwood Street, 01801, Woburn, Massachusetts

    Gary R. Dunn

Authors
  1. Roger W. Melvold
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  2. Henry I. Kohn
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  3. Gary R. Dunn
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Melvold, R.W., Kohn, H.I. & Dunn, G.R. History and genealogy of theH-2K b mutants from the C57BL/6Kh colony. Immunogenetics 15, 177–185 (1982). https://doi.org/10.1007/BF00621950

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  • DOI: https://doi.org/10.1007/BF00621950

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