Summary
We present a case of a 33 year old male with a history of early childhood diarrhoea and more recently diagnosed gluten sensitive enteropathy, who died with active disease, ulcerative proctosigmoiditis and desquamative erythrodermia associated with toxin induced shock. Autopsy revealed a tumour restricted to lymph nodes of the mesentery and the retroperitoneum. This is considered to be malignant histiocytosis of the intestine (MIH). Immunohistological examination of the diagnostic jejunal biopsy showed a pathological binding pattern for peanut lectin (PNL) within the enterocytes. This may be an expression of disturbed production or secretion of a product rich in non-reducing terminal D-galactosyl residues.
References
Booth CC (1970) Enterocyte in coeliac disease —1. Br Med J 3:725–731
Brandt L, Hagander B, Norden Å, Stenstam M (1978) Lymphoma of the small intestine in adult coeliac disease. Acta Med Scand 204:467–470
Cooper BT, Holmes GKT, Cooke WT (1978) Intestinal lymphoma associated with malabsorption. Lancet i/387
Falchuk ZM, Strober W (1974) Gluten-sensitive enteropathy: Synthesis of antigliadin antibody in vitro. Gut 15:947–952
Hodges JE, Isaacson P, Eade OE, Wright R (1979) Serum lysozyme levels in malignant histiocytosis of the intestine. Gut 20:854–857
Isaacson P (1981) Primary gastrointestinal lymphoma. Virchows Arch [Pathol Anat] 391:1–8
Isaacson P, Wright DH (1978a) Malignant histiocytosis of the intestine. Its relation to malabsorption and ulcerative jejunitis. Hum Pathol 9:661–677
Isaacson P, Wright DH (1978b) Intestinal lymphoma associated with malabsorption. Lancet i:67–69
Isaacson P, Wright DH, Judd MA, Mephom BL (1979) Primary gastrontestinal lymphomas. A classification of 66 cases. Cancer 43:1805–1819
Isaacson P, Jones DB, Swarn MJ, Wright DH (1982) Malignant histiocytosis of the intestine: report of three cases with immunological and cytochemical analysis. J Clin Pathol 35:510–516
Kitis G, Holmes GKT, Cooper BT, Thompson H, Allan RN (1980) Association of coeliac disease and inflammatory bowel disease. Gut 21:636–641
Klein PJ, Vierbuchen M, Schulz KD, Würz H, Citoler P, Uhlenbruck G, Ortmann M, Fischer R (1981) Hormonabhängige Lektin-Bindungsstellen: II. Lektinrezeptoren als Indikator einer Hormonsensibilität von Mammacarcinomen. Tumor Diagn 2:240–245
Lotan R, Skutelsky E, Danon D, Sharon N (1975) The purification, composition, and specificity of the anti-T lectin from peanut (Arachis hypogaea). J Biol Chem 250:8518–8523
Marsh MN (1982a) Studies of intestinal lymphoid tissue. The cytology and electron microscopy of gluten-sensitive enteropathy, with particular reference to its immunopathology. Scand J Gastroenterol 16 (Suppl 70) 87–106
Marsh MN (1982b) Studies of intestinal lymphoid tissue. IV. The predicitive value of raised mitotic indices among jejunal epithelial lymphocytes in the diagnosis of glutensensitive enteropathy. J Clin Pathol 35:517–525
Möller P (1982a) Peanut Lectin: A useful tool for detecting Hodgkin cells in paraffin sections. Virchows Arch [Pathol Anat] 396:313–317
Möller P, Schüle B, Kuruc N, Noä G, Landbeck N (1982b) Peanut-lectin-receptoren im lymphknoten. 66. Verh Dtsch Ges Pathol Göttingen
Otto HF, Bettmann I, V Weltzien J, Gebbers J-O (1981) Primary intestinal lymphomas. Virchows Arch [Pathol Anat] 391:9–31
Perkkiö M, Savilahti E, Kuitunen P (1981) Semi-quantitative analysis of complement fractions 3 and 4 in the jejunal mucosae in coeliac disease and in food allergy in childhood. Acta Pathol Microbiol Scand Sect A 89:343–350
Pestalozzi DM, Hess M, Berger EG (1982) Immunohistochemical evidence for cell surface and Golgi localization of galactosyltransferase in human stomach, jejunum, liver and pancreas. J Histochem Cytochem 30:1146–1152
Reisner Y, Gachelin G, Dubois P, Nicolas J-F, Sharon N, Jacob F (1977) Interaction of peanut agglutinin, a lectin specific for non reducing terminal D-galactosyl residues, with embryonal carcinoma cells. Develop Biol 61:20–27
Rose ML, Habeshaw JA, Kennedy R, Sloane J, Wiltshaw E, Davies AJS (1981) Binding of peanut lectin to germinal centre cells: a marker for B-cell subsets of follicular lymphoma? Br J Cancer 44:68–74
Sato S, Spicer SS (1982) Ultrastructural visualization of galactosyl residues in various alimentary epithelial cells with the peanut lectin-horseradish peroxidase procedure. Histochemistry 73:607–624
Scott RB, Robb-Smith AHT (1939) Histiocytic medullary reticulosis. Lancet ii:194–198
Selby WS, Janossy G, Jewell DP (1981) Immunohistological characterization of intraepithelial lymphocytes of the human gastrointestinal tract. Gut 22:169–176
Simpson FG, Bullen AW, Robertson DAF, Losowsky MS (1981) HLA-B8 and the cell mediated immunity to gluten. Gut 22:633–636
Uhlenbruck G, Pardoe GI, Bird GWG (1969) On the specificity of lectins with broad agglutinin spectrum. II. Studies on the nature of the T-antigen and the specific receptors for the lectin of arachis hypogaea (ground-nut). Z Immun Forsch 138:423–433
Ward M, Ferguson A, Eastwood MA (1979) Jejunal lysozyme activity and the Paneth cell in coeliac disease. Gut 20:55–58
Watanabe M, Muramatsu T, Shirane H, Ugai K (1981) Discrete distribution of binding sites for Dolichos biflorus agglutinin (DBA) and for peanut agglutinin (PNA) in mouse organ tissues. J Histochem Cytochem 29:779–790
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Möller, P., Schüle, B., Römmele, U. et al. Conspicuous enterocytic binding pattern for peanut lectin and malignant histiocytosis of the intestine. Vichows Archiv A Pathol Anat 399, 245–253 (1983). https://doi.org/10.1007/BF00619585
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DOI: https://doi.org/10.1007/BF00619585