Summary
Subcutaneous fat from 3 patients with ischemic necrosis of the legs due to arteriosclerotic obstruction were examined histologically and ultrastructurally. Markedly convoluted membranocystic changes were found in all 3 cases. The light and electron microscopic findings of the membranocystic lesions are very similar to those of fat tissue changes in membranous lipodystrophy. Bone lesions and mental disturbance which suggest membranous lipodystrophy, however, were absent in these cases. It is concluded from these results that the membranocystic changes characteristic of membranous lipodystrophy can be produced by circulatory disturbance and the lesions are one of the non-specific changes of adipose tissue.
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Supported by a grant-in-aid for Scientific Research, 1981 and 1982, from the Ministry of Education, Science and Culture, Japanese Government
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Machinami, R. Membranous lipodystrophy-like changes in ischemic necrosis of the legs. Vichows Archiv A Pathol Anat 399, 191–205 (1983). https://doi.org/10.1007/BF00619579
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DOI: https://doi.org/10.1007/BF00619579