Skip to main content
SpringerLink
Log in

Effect of preoperative paracetamol on pain after oral surgery

  • Originals
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

A double-blind, randomized cross-over trial was carried out in 50 patients undergoing surgical removal of bilaterally impacted lower wisdom teeth. Surgery in each patient was performed twice and paracetamol 1000 mg was administered once preoperatively and once postoperatively. The time interval to additional analgesic intake and the pain intensity up to and at that time were assessed. There was no difference between the 2 treatments. It was concluded that preoperative paracetamol does not offer any clinical advantage in patients who undergo surgical removal of impacted lower wisdom teeth.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dionne RA, Cooper SA (1978) Evaluation of preoperative ibuprofen for postoperative pain after removal of third molars. Oral Surg 45: 851–856

    Google Scholar 

  2. Løkken P, Olsen I, Bruaset I, Norman-Pedersen K (1975) Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation. A test with ibuprofen. Eur J Clin Pharmacol 8: 209–216

    Google Scholar 

  3. Mielke CH, Heiden D, Britten AF, Ramos J, Flavell P (1976) Hemostasis, antipyretics, and mild analgesics. Acetaminophen vs Aspirin. J Am Med Assoc 235: 613–616

    Google Scholar 

  4. Ohnhaus EE, Adler R (1975) Methodological problems in the measurement of pain. A comparison between the verbal rating scale and the visual analogue scale. Pain 1: 379–384

    Google Scholar 

  5. Petersen JK (1978) The analgesic and antiinflammatory efficacy of diflunisal and codeine after removal of impacted third molars. Curr Med Res Opin 5: 525–535

    Google Scholar 

  6. Quiding H, Oksala E, Happonen RP, Lehtimäki K, Ojala T (1981) The visual analogue scale in multiple dose evaluations of analgesics. J Clin Pharmacol 21: 424–429

    Google Scholar 

  7. Scott J, Huskisson EC (1976) Graphic representation of pain. Pain 2: 175–184

    Google Scholar 

  8. Skjelbred P, Løkken P (1977) Acetylsalicylic acid vs paracetamol. Effects on post-operative course. Eur J Clin Pharmacol 12: 257–264

    Google Scholar 

  9. Skjelbred P, Løkken P (1979) Paracetamol versus placebo. Effects on post-operative course. Eur J Clin Pharmacol 15: 27–33

    Google Scholar 

  10. Stenbjerg S, Petersen JK (1980) Platlet function and fibrinolytic activity after a single dose of diflunisal (Donobid). Int J Oral Surg 9: 472–476

    Google Scholar 

  11. Wang RIH, Warte E (1981) Crossover and parallel study of oral analgesics. J Clin Pharmacol 21: 162–168

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oral Surgery, University of Umeå, Sweden

    I. Gustafsson, E. Nyström & H. Quiding

  2. Medical Department, Astra Läkemedel AB, Södertälje, Sweden

    I. Gustafsson, E. Nyström & H. Quiding

Authors
  1. I. Gustafsson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Nyström
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Quiding
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gustafsson, I., Nyström, E. & Quiding, H. Effect of preoperative paracetamol on pain after oral surgery. Eur J Clin Pharmacol 24, 63–65 (1983). https://doi.org/10.1007/BF00613928

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00613928

Key words

Search

Navigation