Summary
The effect of indoramin on blood pressure, heart rate and finger blood flow was investigated in eleven patients with essential acrocyanosis. Indoramin 50 mg t. i. d. and placebo were administered for 6 weeks, in random order in a double blind, cross-over trial. In 8 of the 11 patients, finger blood flow, measured by venous occlusion plethysmography was higher and resistance was lower with indoramin. There was no significant change in blood pressure or heart rate. Thus, indoramin may be useful when a decrease in alpha-adrenoreceptor tone in the fingers is desirable.
Similar content being viewed by others
References
Shepherd, J. T.: The physiology of blood flow in the limbs. In: Peripheral Vascular Diseases, p. 63–78, W. B. Saunders 1972
Coffman, J. D., Davies, W. T.: Vasospastic diseases: A review. Prog. Cardiovasc. Dis.18, 123–146 (1975)
Clement, D. L., Pannier, R.: Influence de l'indoramine sur la circulation cutanée chez les sujets vasospastiques. Schweiz. Rund. f. Med.65, 1435–1436 (1976)
Alps, B. J., Hill, M., Johnson, E. S., Wilson, A. B.: Quantitative analysis on isolated organs of the autonomic blocking properties of indoramin hydrochloride (Wy 21 901). Br. J. Pharmacol.44, 52–62 (1972)
Whitney R. J.: The measurement of volume changes in human limbs. J. Physiol.212, 1–27 (1953)
Coltart, D. J., Lockhardt, J. D. F., Royds, R. B., Turner, P.: Human pharmacology of indoramin. Br. J. Pharmacol.43, 467 P (1971)
Boakes, A. I., Prichard, B. N. C., Teoh, P. C.: Alpha-adrenoreceptor inhibition from indoramin in man. Br. J. Pharmacol.44, 378 P (1972)
Lewis, P. J., George, C. F., Dollery, C. T.: Clinical evaluation of indoramin, a new antihypertensive agent. Europ. J. clin. Pharmacol.6, 211–216 (1973)
Royds, R. B., Lockhardt, J. D. F.: The effect of indoramin on peripheral blood flow. Br. J. clin. Pharmacol.1, 13–17 (1974)
Fares, C. M., Milliken, J. C.: The effect of parenteral indoramin on peripheral blood flow in patients with Raynaud's disease or atherosclerosis associated intermittent claudication. Curr. Med. Res.2, 57–62 (1974)
Draffan, G. H., Lewis, P. J., Firmin, J. L., Jordan, T. W., Dollery, C. T.: Pharmacokinetics of indoramin in man. Br. J. Pharmacol.3, 489–495 (1976)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Clement, D.L. Effect of indoramin on finger blood flow in vasospastic patients. Eur J Clin Pharmacol 14, 331–333 (1978). https://doi.org/10.1007/BF00611902
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00611902