Summary
Encainide is a new anti-arrhythmic drug, which is highly effective against ventricular extrasystoles, both single and coupled, in the dose range of 80–140 mg i.v. Ventricular extrasystoles were abolished in 31 out of 33 cases treated. The drug is also relatively effective against supraventricular extrasystoles, but has little effect on atrial fibrillation. Both subjects with clinically normal hearts and those with ischaemic heart disease have been successfully treated. The drug prolongs the QRS and QT duration. Its effectiveness appears to be of the same order of magnitude and the range of indications similar to those of aprindine and lorcainide. Further study of the drug seems to be warranted.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brutsaert, D. L.: Effect of MJ 9067 and lidocaine on myocardial contractility. Technical Report, MJ. (1978)
Byrne, J. E., Gomoll, A. W., Mc Kinney, G. R.: Antiarrhythmic properties of MJ 9067 in acute animal models. J. Pharmacol. Exp. Ther.200, 147–154 (1977)
Carmeliet, E., Janssen, P. A. J., Marsboom, R., Van Nueten, J. M., Xhonneux, R.: Anti-arrhythmic, electrophysiologic and hemodynamic effects of lorcainide. Arch. Int. Pharmacodyn. Ther.231, 104–130 (1978)
Carmeliet, E., Verdonck, F.: Effect of aprindine and lidocaine in transmembrane potentials and radio-active K efflux in different cardiac tissues. Acta Cardiol. Suppl.13, 73–90 (1974)
Gomoll, A. W.: Electrophysiological effects of MJ 9067. Biological Research Stage II Report (1977)
Hondeghem, L. M., Katzung, B. G.: Time and voltage dependent interactions of anti-arrhythmic drugs with cardiac sodium channels. Biochim. Biophys. Acta.472, 373–398 (1977)
Kesteloot, H.: General aspects of anti-arrhythmic treatment with aprindine. Acta Cardiol. Suppl.13, 303–316 (1974)
Kesteloot, H., Stroobandt, R.: Clinical experience with lorcainide (R 15889), a new anti-arrhythmic drug. Arch. Int. Ther.230, 225–234 (1977)
Lasseter, K. C.: The patient with an arrhythmia. Drug Therapy1977, 122–126
Mayol, R. F.: Development of radio-immunoassay for MJ 9067 and measurement of MJ 9067 in plasma from a single dose oral and intravenous. Mayo RF, Drug Metabolism Report, 1976
Piessens, J., Willems, J., Kesteloot, H., De Geest, H.: Effects of aprindine on left ventricular contractility in man. Acta Cardiol. Suppl.18, 203–216 (1974)
Zipes, D. P., Elharrar, V., Noble, R. J., Gaum, W. E., Troup, P. J., Fasola, A.: Effects of various drugs on ventricular conduction delay and ventricular arrhythmias during myocardial ischemia in the dog. Re-entrant arrhythmias. Kulbertus, H. (ed.) Lancaster: M. T. P. Press 1977
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kesteloot, H., Stroobandt, R. Clinical experience of encainide (MJ 9067): A new anti-arrhythmic drug. Eur J Clin Pharmacol 16, 323–326 (1979). https://doi.org/10.1007/BF00605629
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00605629