Abstract
The age-dependent occurrence of cervical degenerative changes was studies using 0.1 T MRI in 89 asymptomatic volunteers aged 9 to 63 years. The degree of DD (disc darkening on T2*-weighted images), disc protrusions and prolapses, narrowing of disc spaces, dorsal osteophytes and spinal canal stenosis were assessed. Abnormalities were commoner in older subjects, 62% of being seen in those over 40 years old. In subjects aged less than 30 years there were virtually no abnormalities. DD was the most common abnormality, seen in 10% of discs; 57% DD was in subjects aged over 40. DD at the C5/6 level was the most common finding. No differences in abnormal findings between males and females was observed, nor any statistically significant association between DD and other abnormalities. Thus, DD begins later age in the cervical spine than in the lumbar region. Asymptomatic degenerative changes are common on MRI in the cervical spine after 30 years of age.
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Kvarnström S (1983) Occurence of musculoskeletal disorders in a manufacturing industry, with special attention to occupational shoulder disorder. Scand J Rehab Med (Suppl 8)
Hult L (1959) The Munkfors investigation. Acta Orthop Scand 16 (Suppl):21–35
Simeone FE (1992) Cervical disc disease with radioculopathy. In: Rothman RH and Simeone FA (eds) The Spine, 3rd Edn. Saunders, Philadelphia, pp 553–554
Russell EJ (1990) Cervical disk disease. Radiology 177:313–325
Miller JAA, Schmatz C, Schultz AB (1988) Lumbar disc degeneration: correlation with age, sex and spine level in 600 autopsy specimens. Spine 13:173–178
Tertti MO, Salminen JJ, Paajanen HEK, Terho PH, Kormano MJ (1991) Low-back pain and disk degeneration in children: a case-control MR imaging study. Radiology 180:503–507
Friedenberg ZB, Miller WT (1963) Degenerative disc disease of the cervical spine. A comparative study of asymptomatic and symptomatic patients. J Bone J Surg [Am] 45:1171–1178
Gore DR, Sepic SB, Gardner GM (1986) Roentgenographic findings of the cervical spine in asymptomatic people. Spine 11: 521–524
McRae DL (1960) The significance of abnormalities of the cervical spine. Am J Roentgenol 84:3–25
Gore DR, Sepic SB, Gardner GM, Murray MP (1987) Neck pain: a long-term follow-up of 205 patients. Spine 12:1–5
Modic MT, Masaryk TJ, Ross JS, Carter JR (1988) Imaging of degenerative disk disease. Radiology 168:177–186
Tertti M, Paajanen H, Laato M, Aho H, Komu M, Kormano M (1991) Disc degeneration in magnetic resonance imaging: A comparative biochemical, histologic and radiologic study in cadaver spines. Spine 16:629–634
Enzmann DR, Rubin JR (1988) Cervical spine: MR imaging with a partial flip angle, gradient-refocused pulse sequence. Part I. General considerations and disk disease. Radiology 166:467–472
Modic MT, Pavlicek W, Weinstein MA, et al (1984) Magnetic resonance imaging of intervertebral disk disease. Radiology 152: 103–111
Jenkins JPR, Hickey DS, Zhu XP, Machin M, Isherwood I (1985) MR imaging of the intervertebral disc: a quantitative study. Br J Radiol 58:705–709
Boden SD, McCowin PR, Davis DO, Dina TS, Mark AS, Wiesel S (1990) Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. J Bone J Surg [Am] 72:1178–1184
Herkowitz HN, Kurz LT, Overholt DP (1990) Surgical management of cervical soft tissue disc herniation. A comparison between the anterior and posterior approach. Spine 15: 1026–1030
Teresi LM, Lufkin RB, Reicher MA, et al (1987) Asymptomatic degenerative disk disease and spondylosis of the cervical spine: MR imaging. Radiology 164:83–88
Paajanen H, Erkintalo M, Dahlström S, Kuusela T, Svedström E, Kormano M (1989) Disc degeneration and lumbar instability. Magnetic resonance examination of 16 patients. Acta Orthop Scand 60:375–378
Bottomley PA, Foster TH, Argesinger RE, Pfeiffer LM (1984) A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1–100 MHz: dependence on tissue type, NMR frequency, temperature, species, excision and age. Med Phys 11:425–448
Dixon WJ (1983) BMDP statistical software. Berkeley, University of California Press
Powell MC, Wilson M, Szypryt P, Symonds EM (1986) Prevalence of lumbar disc degeneration observed by magnetic resonance in symptomless women. Lancet 1366–1367
Pritzker KP (1977) Aging and degeneration in the lumbar intervertebral dise. Orthop Clin North Am 8:65–77
Jacobs B, Ghelman B, Marchisello P (1990) Coexistence of cervical and lumbar disc disease. Spine 15:1261–1264
Wagner M, Sether LA, Ho PSP, Houghton VM (1988) Age changes in the lumbar intervertebral disc studied with magnetic resonance and cryomicrotomy. Clin Anat 1:93–103
Sether LA, Yu S, Haughton VM, Fischer ME (1990) Intervertebral disk: normal age-related changes in MR signal-intensity. Radiology 177:385–388
Ho PSP, Yu S, Sether LA, Wagner M, Ho K-C, Haughton VM (1988) Progressive and regressive changes in the nucleus pulposus. Part I. The neonate. Radiology 169:87–91
Oda J, Tanaka H, Tsuzuki N (1988) Intervertebral disc changes with aging of human cervical vertebra. From the neonate to the eighties. Spine 13:1206–1211
Yu S, haughton VM, Ho PSP, Sether LA, Wagner M, Ho K-C (1988) Progressive and regressive changes in the nucleus pulposus. Part II. The adult. Radiology 169:93–97
Mills TC, Ortendahl DA, Hylton NM, Crooks LE, Carson JW, Kaufman L (1987) Partial flip angle MR imaging. Radiology 162: 531–539
Winkler ML, Ortendahl DA, Mills TC, et al (1988) Characteristics of partial flip angle and gradient reversal MR imaging. Radiology 166:17–26
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Lehto, I.J., Tertti, M.O., Komu, M.E. et al. Age-related MRI changes at 0.1 T in cervical discs in asymptomatic subjects. Neuroradiology 36, 49–53 (1994). https://doi.org/10.1007/BF00599196
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DOI: https://doi.org/10.1007/BF00599196