Summary
Results of measurements of the penetration rate of14C-labelled hydrocortisone butyrate (HCB) under varying conditions (cream or alcoholic solution as a vehicle, variation of the concentration and/or amount applied) are presented. Alcoholic solutions gave the highest penetration.
The amount of HCB present on the interface between the vehicle and the epidermis proved to be the rate-limiting factor under our experimental conditions.
Zusammenfassung
Die Penetrationsrate von14C-markiertem Hydrocortisonbutyrat (HCB) wurde unter verschiedenen Bedingungen (Creme oder alkoholische Lösung als Vehikel, unterschiedliche Konzentrationen und Mengen) gemessen. Alkoholische Lösungen zeigten die größte Penetrationsrate. Die an der Grenzzone zwischen Epidermis und Vehikel befindliche HCB-Menge erwies sich unter den verwandten Versuchsbedingungen als ausschlaggebend für die Penetrationsrate.
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Ponec, M., Polano, M.K. Hydrocortisone butyrate penetration through epidermis in vitro. Arch. Derm. Forsch. 245, 381–389 (1972). https://doi.org/10.1007/BF00595642
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DOI: https://doi.org/10.1007/BF00595642