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Makrophagenrekrutierung aus Blutmonocyten bei Entzündungsreaktionen der Haut

Macrophage-recruitment from blood monocytes in inflammatory skin reactions

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Summary

Transfusion of3HDFP labeled autologous monocytes was performed in healthy probants. Subsequently labeling indices of blood monocytes and of macrophages in skin window exsudates were determined. The results demonstrated that macrophages of acute inflammatory skin reactions are directly recruited from circulating monocytes. In addition, 4 patients suffering from generalized, chronic eczematous skin diseases were examined. Monocyte turnover rates were normal in 3 of these patients and slightly increased in the fourth. Obviously the macrophage pools at the side of these wide spread chronic inflammatory reactions were composed of self-sustaining and self-renewing macrophage populations with low monocyte recruitment rates.

Zusammenfassung

Gesunden Probanden wurden autologe,3HDFP markierte Monocyten transfundiert und dann die Markierungsindices der Blutmonocyten und der Makrophagen im Hautfensterexsudat bestimmt. Die Ergebnisse zeigten, daß die Makrophagenbesiedlung der akut entzündlichen Hautfensterreaktion durch direkte Rekrutierung aus Blutmonocyten erfolgt. Außerdem wurden vier Patienten mit generalisierten, chronischen Ekzemen untersucht (Neurodermitis, aus bakteriellseborrhoischem Ekzem entstandene Erythrodermie, generalisierte chronische Ekzeme bei Kontaktallergie). Bei drei dieser Patienten lagen die Monocytenumsatzraten im Normbereich, bei dem vierten war sie geringfügig gesteigert. Die Makrophagenspeicher im Gebiet dieser ausgedehnten, chronischen Entzündungen setzten sich offensichtlich aus Makrophagenpopulationen zusammen, die in der Lage waren, ihren Bestand weitgehend unabhängig von der Monocytenrekrutierung zu erhalten und zu erneuern.

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Authors and Affiliations

  1. Nuklearmedizinische Abteilung der Medizinischen Universitätsklinik Freiburg, Germany

    G. Meuret, A. Marwendel & E. T. Brand

  2. Universitäts-Hautklinik Freiburg, Germany

    G. Meuret, A. Marwendel & E. T. Brand

Authors
  1. G. Meuret
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  2. A. Marwendel
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  3. E. T. Brand
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Additional information

Die Untersuchungen wurden durch die Deutsche Forschungsgemeinschaft unterstützt.

Unter technischer Assistenz von B. Kasten.

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Meuret, G., Marwendel, A. & Brand, E.T. Makrophagenrekrutierung aus Blutmonocyten bei Entzündungsreaktionen der Haut. Arch. Derm. Forsch. 245, 254–266 (1972). https://doi.org/10.1007/BF00595143

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  • DOI: https://doi.org/10.1007/BF00595143

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