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Unidirectional rate sensitivity component in local control of vascular tone

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Summary

A one second square wave decrease or increase in perfusion pressure induced active vasodilatation in the vascular bed of gracilis muscle. The peak time of this response is 4.42±0.32 and 3.52±0.25 sec respectively and its duration is 24.8±3.9 and 24.5±2.9 sec respectively.

The dilator response (that first value always refers to the pressure decrease and the second for the pressure increase) is:

  1. a)

    Directly proportional to the amplitude of perfusion pressure change up to an amplitude of 73.9±2.3 and 78.4±1.8 mm Hg respectively. The vascular resistance decreases to 29.6±1.7 and 32.2±1.8% respectively of the resting value. Further increase of the amplitude show no statistically significant influence.

  2. b)

    Dependent on the perfusion pressure. Within the range of perfusion pressures of 78.6±1.9 to 113.6±2.3 mm Hg and 77.5±2.7 to 112.3±4.2 mm Hg respectively a maximal response occurs.

  3. c)

    The duration of the vasodilatation is directly proportional to the amplitude of the perfusion pressure change. From the lowest to the highest amplitudes the duration of the response was prolonged from 15.8±2.2 to 30.3±5.3 sec and from 17.5±1.6 to 28.1±4.3 sec respectively.

The agreement in all of the parameters indicates that the mechanism of this vasodilatation is independent of the polarity of the pressure change. Analysis of the results confirmed that the vascular response is based on a unidirectional sensitivity of the system of local control of blood flow to the ascending component of the perfusion pressure change. It is proposed that two types of myogenic vascular response in skeletal muscle should be differentiated:

1. the Bayliss' response to change in the perfusion pressure level, and 2. the vasodilatory response to the ascending component of this pressure change.

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  1. Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Sienkiewiczova 1, Bratislava, Czechoslovakia

    V. Smieško

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  1. V. Smieško
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Smieško, V. Unidirectional rate sensitivity component in local control of vascular tone. Pflugers Arch. 327, 324–336 (1971). https://doi.org/10.1007/BF00588451

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  • DOI: https://doi.org/10.1007/BF00588451

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