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Diagnostic role of gadolinium-DTPA in pediatric neuroradiology

A retrospective review of 655 cases

  • Diagnostic Neuroradiology
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Summary

We retrospectively reviewed the findings in 655 consecutive young patients who underwent contrastenhanced MR examinations (1.5T) of the head or spine. Their ages ranged from 4 months to 20 years (mean 10 years). There was a 1.7% incidence of minor adverse reactions to gadolinium (Gd)-DTPA, none of which required treatment; no serious adverse reactions were encountered. Based on the radiologic diagnosis the patients were divided into three groups: (1) normal, (2) CNS neoplasm, (3) abnormal but not neoplasm. There were 178 patients thought to have CNS neoplasms and of these 156 (88%) enhanced. Of 124 histologically confirmed neoplasms 115 (93%) showed enhancement after Gd-DTPA. Eight children had histologically confirmed spinal neoplasms; 5 of 6 neurofibromas and 2 ependymomas enhanced. In the 216 patients with abnormalities thought not to be neoplastic, the enhancement rate was 11%; most of the enhancing lesions were vascular malformations. There were very few examples of inflammatory disease, acute trauma or stroke among our patients.

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Author notes

  1. H. -L. Ge & G. L. Wolf

    Present address: MGH-NMR Center, Bldg. 149, 13th St., Charlestown, Massachusetts, USA

  2. R. A. Rubin

    Present address: Department of Radiology, Presbyterian-University Hospital, DeSoto at O'Hara Sts., Pittsburgh, Pennsylvania, USA

  3. R. K. Hackett

    Present address: Department of Radiology, Latrobe Area Hospital, West Second Ave., Latrobe, Pennsylvania, USA

Authors and Affiliations

  1. Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    H. -L. Ge, W. L. Hirsch, G. L. Wolf, R. A. Rubin & R. K. Hackett

  2. the Pittsburgh NMR Institute, Pittsburgh, Pennsylvania, USA

    H. -L. Ge, W. L. Hirsch, G. L. Wolf, R. A. Rubin & R. K. Hackett

  3. Department of Radiology, the VAMC, Pittsburgh, Pennsylvania, USA

    H. -L. Ge, W. L. Hirsch, G. L. Wolf, R. A. Rubin & R. K. Hackett

Authors
  1. H. -L. Ge
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  2. W. L. Hirsch
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  3. G. L. Wolf
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  4. R. A. Rubin
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  5. R. K. Hackett
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Ge, H.L., Hirsch, W.L., Wolf, G.L. et al. Diagnostic role of gadolinium-DTPA in pediatric neuroradiology. Neuroradiology 34, 122–125 (1992). https://doi.org/10.1007/BF00588157

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  • DOI: https://doi.org/10.1007/BF00588157

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