Abstract
Pancreatic blood flow rates were determined using a133Xe washout technique in a total of 40 dogs, 14 of which were used as a control group and the remaining 26 as the experimental group. The initial pancreatic blood flow rates of control group and of the experimental group were 85.1±10.1 ml/100g/min of pancreas/min and 81.1±5.4 ml/100g/min respectively. These values were not significantly different from each other (P>0.05). In the control group the blood flow was determined 3 times at 30 min intervals. These mean values were 73.0±9.4, 74.6±8.7, and 79.4 ±10.4 ml/100g/min respectively (P>0.05). The dogs in the experimental group were bled and the peripheral arterial blood pressure was reduced stepwise to 80, 50, and 30 mm Hg. At each level a 30 min of stabilization period the pancreatic blood flow rates were 49.8±3.7, 29.3±2.3 and 20.2±2.3 ml/100g/min respectively. These mean values were very significantly reduced compared to those of the control group, at 30 min (P<0.02), at 60 and 90 min (P>0.001). They were also very significantly different from their own initial values (P<0.001). the metabolic consequences of this reduction in pancreatic blood flow are discussed.
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This study was supported in part by grants No. 264 and 315 of Turkish Scientific and Technical Research Council
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Bor, N.M., Alvur, M., Ercan, M.T. et al. Pancreatic blood flow in hemorrhagic shock. Pflugers Arch. 386, 277–280 (1980). https://doi.org/10.1007/BF00587479
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DOI: https://doi.org/10.1007/BF00587479