Summary
Slow inward currents are here reported in frog skeletal muscle. The currents are turned on by depolarising the membrane beyound about −45 mV, and are blocked by replacement of Ca2+ by Mg2+ and in the presence of Ca2+ by Co2+ at 20mM.
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Kao, C.Y. (1966). Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena. Pharmac. Rev.18, 997–1049.
Stanfield, P.R. (1970). The effect of the tetraethylammonium ion on the delayed currents of frog skeletal muscle. J. Physiol.209, 209–229.
Stanfield, P.R. (1970). The differential effects of tetraethylammonium and zinc ions on the resting conductance of frog skeletal muscle. J. Physiol.209, 231–256.
Beaty, G.N. & Stefani, E. (1976). Calcium dependent electrical activity in twitch muscle fibres of the frog. Proc. R. Soc. B.194, 141–150.
Beaty, G.N. & Stefani, E. (1976). Inward calcium current in twitch muscle fibres of the frog. J. Physiol.260, 27P.
Bernard, C., Cardinaux, J.C. & Potreau, D. (1976). Long-duration responses and slow inward current obtained from isolated skeletal muscle fibres with barium ions. J. Physiol.256, 18P.
Adrian, R.H., Chandler, W.K. & Hodgkin, A.L. (1970). Voltage clamp experiments in striated muscle fibres. J. Physiol.208, 607–644.
Hodgkin, A.L. & Horowicz, P. (1959). The influence of potassium and chloride ions on the membrane potential of single muscle fibres. J. Physiol.148, 127–160.
Reuter, J. (1973). Divalent cations as charge carriers in excitable membranes. Prog. Biophys.26, 1–43.
Noble, D. & Hall, A.E. (1965). The conditions for initiating all-or-nothing repolarization in cardiac muscle. Biophys. J.3, 261–274.
Jack, J.B., Noble, D. & Tsien, R.W. Electric current flow in excitable cells. Oxford University Press 1975.
Argibay, J.A. & Hutter, O.F. (1973). Voltage clamp experiments on the inactivation of the delayed potassium current in skeletal muscle fibres. J. Physiol.232, 41–43P.
Howarth, J.V. (1958). The behaviour of frog muscle in hypertonic solutions. J. Physiol.144, 167–175.
Armstrong, C.M., Bezanilla, F.M. & Horowicz, P. (1972). Twitches in the presence of ethyleneglycol bis (β-aminoethyl ether)-N,N-tetra-acetic acid. Biochim. biophys. Acta.267, 605–608.
Solandt, D.Y. (1936). The effect of potassium on the excitability and resting metabolism of frog's muscle. J. Physiol.86, 162–170.
Van der Kloot, W.G. (1967). Potassium stimulated respiration and intracellular calcium release in frog skeletal muscle. J. Physiol.191, 141–165.
Hodgkin, A.L. & Horowicz, P. (1960). Potassium contractures in single muscle fibres. J. Physiol.153, 386–403.
Kao, C.Y. & Stanfield, P.R. (1968). Actions of some anions on electrical properties and mechanical threshold of frog twitch muscle. J. Physiol.198, 291–309.
Kao, C.Y. & Stanfield, P.R. (1970). Actions of some cations on the electrical properties and mechanical threshold of frog sartorius muscle fibres. J. gen. Physiol.55, 620–639.
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Stanfield, P.R. A calcium dependent inward current in frog skeletal muscle fibres. Pflugers Arch. 368, 267–270 (1977). https://doi.org/10.1007/BF00585206
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DOI: https://doi.org/10.1007/BF00585206