Abstract
Hypothyroid hamsters had a reduced capacity for heat production in the cold. This was correlated with a reduction of nonshivering thermogenesis (NST) as measured following an injection of tyramine, thereby releasing endogenous stores of noradrenaline (NA). However, when NST was measured following an injection of NA, the same capacity was found in controls and hypothyroid hamsters. This suggests that hypothyroidism decreased the availability of endogenous transmitters for cold induced stimulation of NST.
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Brück, K., Wünnenberg, W., Zeisberger, E.: Comparison of cold adaptive modifications in different species, with special reference to the miniature pig. Fed. Proc. 28: 1035–1041 (1969)
Fregly, M.J., Field, F.P., Katovich, M.J., Barney, C.C.: Catecholamine-thyroid hormone interaction in cold acclimated rats. Fed. Proc. 38, 2162–2169 (1979)
Heldmaier, G., Steinlechner, S., Rafael, J., Vsiansky, P.: Photoperiodic control and effects of melatonin on nonshivering thermogenesis and brown adipose tissue. Science 212, 917–919 (1981)
Hsieh, A.C.L., Carlson, L.: Role of the thyroid in metabolic response to low temperature. Am. J. Physiol. 188, 40–44 (1957)
Jansky, L.: Nonshivering thermogenesis and its thermoregulatory significance. Biol. Rev. 48, 85–132 (1973)
Kennedy, D.R., Hammond, R.P., Hamolsky, M.W.: Thyroid cold acclimation influences on norepinephrine metabolism in brown fat. Am. J. Physiol. 232, E565-E569 (1977)
LeBlanc, J.: Man in the cold. C. C. Thomas, Springfield Illinois (1975)
LeBlanc, J., Villemaire, A.: Thyroxine and noradrenaline on noradrenaline sensitivity, cold resistance and brown fat. Am. J. Physiol. 218, 1742–1745 (1970)
Lefkowitz, R.J.: Identification and regulation of alpha- and beta-adrenergic receptors Fed. Proc. 37, 123–129 (1978)
Lynch, G.R., White, S.E., Grundel R., Berger, M.S.: Effects of photoperiod, melatonin administration and thyroid block on spontaneous daily torpor and temperature regulation in the white-footed mouse, Peromyscus leucopus. J. comp. Physiol. 125, 157–163 (1978)
Malbon, C.C., Moreno, F.J., Cabelli, R.J., Nain, J.N.: Fat cell adenylate cyclase and beta-adrenergic receptors in alterd thyroid states. J. Biol. Chem. 253, 671–678 (1978)
Scarpace, P.J., Abrass, I.B.: Thyroid hormone regulation of beta-adrenergic receptor number in aging rats. Endocrinology 108, 1276–1278 (1981)
Sundin, U.: The influence of thyroxine on brown fat thermogenesis. Int. Cong. Physiol., Sci., Pecs, 1980.
Tse, J., Wrenn, R.W., Kuo, J.F.: Thyroxine induced changes in characteristics and activities of beta-adrenergic receptors and adenosine-3′,5′-monophosphate and guanosine-3′,5′-monophosphate systems in the heart may be related to reputed catecholamine supersensitivity in Hyperthyroidism. Endocrinology 107, 6–16 (1980)
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Supported by the Deutsche Forschungsgemeinschaft (He 990)
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Seidel, A., Heldmaier, G. Thyroid hormones affect the physiological availability of nonshivering thermogenesis. Pflugers Arch. 393, 283–285 (1982). https://doi.org/10.1007/BF00584085
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DOI: https://doi.org/10.1007/BF00584085