Abstract
The metabolic responses to electrical nerve stimulation, norepinephrine or octanoate additions were studied using continuous monitoring of NAD(P)H/NADP redox state by reflexion spectrophotometry of interscapular brown adipose tissues from control and ventromedial hypothalamic (VMH) lesioned rats. The responses to these stimuli were all greatly decreased already 3 days after VMH lesions, indicating a reduced cell capacity to oxidize free fatty acids. Measurements of interscapular brown adipose tissue composition 4–5 weeks after VMH lesions showed a decrease of both DNA concentration and total content, indicating some tissue involution.
It is concluded that the involvement of the ventromedial bypothalamus in the activation of brown adipose tissue provided a possible anatomical clue concerning pathways connecting thermal and weight regulations.
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Seydoux, J., Rohner-Jeanrenaud, F., Assimacopoulos-Jeannet, F. et al. Functional disconnection of brown adipose tissue in hypothalamic obesity in rats. Pflugers Arch. 390, 1–4 (1981). https://doi.org/10.1007/BF00582702
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DOI: https://doi.org/10.1007/BF00582702